Document Detail

A case of endodermal sinus tumor associated with the first pregnancy and successful management of the second pregnancy: a case report and review of the literature.
MedLine Citation:
PMID:  17479685     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Pregnancy complicated by endodermal sinus tumor (EST) of the ovary has rarely been reported. CASE: A huge ovarian EST causing bowel obstruction was found in a 22-year-old patient at 34 weeks of gestation. Abnormally high alpha-fetoprotein (AFP) levels suggested a malignant germ cell tumor of the ovary. The patient was submitted to cesarean section and fertility sparing surgery, and then received four courses of combination chemotherapy. There was no evidence of recurrence 19 months after initial treatment but transvaginal ultrasound (US) evaluation showed an intrauterine pregnancy of six weeks. We delivered a 3,200 g healthy male baby with Apgar scores of 8 and 9 by elective cesarean section at 39 weeks of gestation. CONCLUSIONS: Successful outcome of a second pregnancy is possible after treatment with fertility sparing surgery and combination chemotherapy for an endodermal sinus tumor associated with a first pregnancy. Moreover checking of weekly AFP levels and performing monthly abdominal US could be effective for surveillance of these pregnancies. However management of EST during pregnancy should be based on consideration of the patient's presenting condition, preferences, and gestational age.
S Ayas; I Aköz; E Eskicirak; A Karateke; O Bozoklu
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  European journal of gynaecological oncology     Volume:  28     ISSN:  0392-2936     ISO Abbreviation:  Eur. J. Gynaecol. Oncol.     Publication Date:  2007  
Date Detail:
Created Date:  2007-05-07     Completed Date:  2007-06-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100357     Medline TA:  Eur J Gynaecol Oncol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  155-9     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Zeynep Kamil Women's and Children's Hospital, Istanbul, Turkey.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Endodermal Sinus Tumor / diagnosis*,  drug therapy*
Ovarian Neoplasms / diagnosis*,  drug therapy*
Pregnancy Complications, Neoplastic / diagnosis*,  drug therapy*
Pregnancy Outcome
Pregnancy Trimester, Third
Treatment Outcome
alpha-Fetoproteins / analysis
Reg. No./Substance:

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