Document Detail

A case of daptomycin-induced immune thrombocytopenia.
MedLine Citation:
PMID:  23027187     Owner:  NLM     Status:  MEDLINE    
We report a case of severe daptomycin-induced immune thrombocytopenia in a patient treated for methicillin-resistant Staphylococcus epidermidis and ampicillin-resistant Enterococcus faecalis bacteremia acquired in an intensive care unit. Serum antibodies bound to platelets in the presence of daptomycin on flow cytometry. There was no evidence of other causes of thrombocytopenia. The patient died of brain herniation complicating extensive cerebral hemorrhage. To our knowledge, this is the first described case of daptomycin-induced thrombocytopenia.
Charles Grégoire; Caren Brumpt; Delphine Loirat; Nicolas Lau; Cedric Bruel; Francois Philippart; Carine Couzigou; Maité Garrouste-Orgeas; Benoit Misset
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2012-10-01
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  56     ISSN:  1098-6596     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-13     Completed Date:  2013-02-28     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6430-1     Citation Subset:  IM    
Intensive Care Unit, Saint Joseph Hospital Network, Paris, France.
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MeSH Terms
Abdominal Abscess / drug therapy,  microbiology
Ampicillin Resistance
Anti-Bacterial Agents / adverse effects*,  therapeutic use
Daptomycin / adverse effects*,  therapeutic use
Enterococcus faecalis
Fatal Outcome
Flow Cytometry
Gram-Positive Bacterial Infections / complications,  drug therapy
Intracranial Hemorrhages / etiology
Mesenteric Veins
Methicillin-Resistant Staphylococcus aureus
Middle Aged
Platelet Transfusion
Pseudomonas Infections / complications,  drug therapy
Shock, Septic / complications,  drug therapy
Staphylococcal Infections / complications,  drug therapy
Thrombocytopenia / chemically induced*,  immunology,  therapy
Venous Thrombosis / complications
Reg. No./Substance:
0/Anti-Bacterial Agents; 103060-53-3/Daptomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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