Document Detail

A case-controlled study of cognitive progression in Chinese lacunar stroke patients.
MedLine Citation:
PMID:  18456396     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: (1) To determine and compare the rates of cognitive change using global and executive psychometric measures between lacunar stroke patients and matched controls and; (2) to identify features associated with cognitive changes in patients. METHODS: Sixty-one lacunar stroke patients and 35 demographically-matched controls were followed-up for 28.6 months (range 19.4-45.9 months) with psychometric assessments performed at baseline and follow-up. RESULTS: Lacunar stroke patients were more impaired than controls in general and executive functions at both time points. Both groups had similar stability in all psychometric tests. Patients, but not controls, exhibited a trend for improvement in general cognitive functions overtime (interaction term, p=0.084). No patient who was non-demented at baseline became demented during the study period. Two (5.7%) and five (8.2%) incident cerebrovascular events occurred among the controls and patients, respectively. Linear regression analyses performed upon patients failed to identify any predictor for the cognitive change. CONCLUSION: Similar to controls, cognition in lacunar stroke patients is stable during the first 2-3 years after the stroke. There maybe a spontaneous improvement in general cognition overtime, but this awaits confirmation by future studies.
Vincent C Mok; Adrian Wong; Wynnie W Lam; Lawrence W Baum; Ho Keung Ng; Lawrence Wong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-05-05
Journal Detail:
Title:  Clinical neurology and neurosurgery     Volume:  110     ISSN:  0303-8467     ISO Abbreviation:  Clin Neurol Neurosurg     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-14     Completed Date:  2008-09-15     Revised Date:  2009-10-14    
Medline Journal Info:
Nlm Unique ID:  7502039     Medline TA:  Clin Neurol Neurosurg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  649-56     Citation Subset:  IM    
Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, China.
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MeSH Terms
Aged, 80 and over
Asian Continental Ancestry Group
Brain Infarction / ethnology,  physiopathology*,  psychology
Case-Control Studies
Cognition / physiology*
Cognition Disorders / physiopathology*,  psychology
Disease Progression
Follow-Up Studies
Linear Models
Magnetic Resonance Imaging
Middle Aged
Neuropsychological Tests / standards,  statistics & numerical data
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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