Document Detail

A case control study of renal transplantation in patients with type I diabetes.
MedLine Citation:
PMID:  10147945     Owner:  NLM     Status:  MEDLINE    
A case control study was undertaken comparing the outcome of 208 renal allografts transplanted into diabetic recipients with those transplanted into an appropriately matched group of non-diabetic recipients. In each group there were 151 cadaver, 21 two-haplotype identical, 35 one-haplotype identical, and one zero-haplotype identical living-related grafts. For the entire group of diabetics, 1- and 5-year graft survivals were 71.3% and 46%. Graft survivals for the non-diabetic recipients at 1 and 5 yr were 81.8% and 57.8% (p less than 0.05). In all patient subgroups divided according to the donor source, the graft and patient survival rates for the non-diabetic recipients exceeded those of the diabetic recipients. One- and 5-yr diabetic patient survivals were 90% and 70%, and for the non-diabetics they were 97% and 95%, respectively (p less than 0.001). There were 40 deaths among diabetics and 15 among the non-diabetics. Cardiovascular disease was the major cause of death in the diabetics, accounting for 40% of the deaths. In addition, allograft loss due to patient death was a significant cause of graft loss in the diabetic group, 24 grafts (28%). Seven grafts (10%) were lost due to patient death in the non-diabetic group (p less than 0.05). Post-transplant, diabetic recipients had a greater incidence of stroke, angina, myocardial infarction, peripheral vascular disease, urinary tract infections (p less than 0.01 for each), and wound infections (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
J L Munson; W M Bennett; J M Barry; D J Norman
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Clinical transplantation     Volume:  6     ISSN:  0902-0063     ISO Abbreviation:  Clin Transplant     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1993-02-25     Completed Date:  1993-02-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8710240     Medline TA:  Clin Transplant     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  306-11     Citation Subset:  T    
Divisions of Nephrology and Urology, Oregon Health Sciences University, Portland 97291.
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MeSH Terms
Case-Control Studies
Diabetes Mellitus, Type 1 / surgery*
Graft Rejection
Graft Survival
Kidney Transplantation / adverse effects,  mortality*
Postoperative Complications
Survival Rate
Vascular Diseases / complications

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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