| A case-control study of plasma ascorbate and acute necrotizing ulcerative gingivitis. | |
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MedLine Citation:
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PMID: 3163353 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Data from animal studies and from studies of patients with acute necrotizing ulcerative gingivitis (ANUG) have provided suggestive evidence for an association between ascorbate deficiency and disease risk. Further, there is biological plausibility for such an association, due to the role of ascorbate in collagen synthesis and leukocyte function. A case-control study of plasma ascorbate and ANUG was performed on 60 patients with a history of ANUG infection and 60 age-race-sex-matched controls. No cases had had active lesions for at least two months prior to their vitamin assay to avoid any potential reduction of dietary intake of ascorbic acid due to the presence of painful mouth lesions. According to results obtained by use of a modification of the 2,4-dinitrophenylhydrazine method for determination of total plasma ascorbate, the mean and standard error of the mean of plasma ascorbate for all ANUG cases was 0.07 +/- 0.006 mmol/L; the mean for all controls was 0.10 +/- 0.006 mmol/L. Paired differences in plasma ascorbic acid concentrations between cases and controls were significantly different from zero (p less than 0.001). The unadjusted relative risk (RR) of ANUG as obtained by conditional logistic regression for subjects whose plasma ascorbic acid concentration was at or below the median value for controls, relative to subjects with higher values, was 7.3 (90% confidence interval, 3.0 - 17.4; one-sided p value less than 0.001). Patients with a history of ANUG ingested a daily average of 1.2 +/- 0.2 servings of dietary ascorbic acid, as compared with a daily average of 1.9 +/- 0.2 servings for healthy controls.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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S L Melnick; J O Alvarez; J M Navia; R B Cogen; J M Roseman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of dental research Volume: 67 ISSN: 0022-0345 ISO Abbreviation: J. Dent. Res. Publication Date: 1988 May |
Date Detail:
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Created Date: 1988-06-15 Completed Date: 1988-06-15 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0354343 Medline TA: J Dent Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 855-60 Citation Subset: D; IM |
Affiliation:
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Department of Epidemiology, School of Public Health, University of Alabama at Birmingham 35294. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Ascorbic Acid / administration & dosage, blood* Diet Female Gingivitis, Necrotizing Ulcerative / blood* Humans Male Oral Hygiene Smoking / blood Social Class Stress, Psychological / blood |
| Grant Support | |
ID/Acronym/Agency:
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DE-06551/DE/NIDCR NIH HHS; DE-07132/DE/NIDCR NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-81-7/Ascorbic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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