| A case-control study of multiple sclerosis. | |
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MedLine Citation:
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PMID: 2725877 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We conducted a study of 145 persons with multiple sclerosis who had been identified in a 1970 survey and 145 friend controls, to investigate whether the development of MS was associated with exposure to uncommon viruses or an older age at infection with 1 or more common viruses. The most striking finding was a strong positive association for history of infectious mononucleosis (IM), suggesting older age at exposure to Epstein-Barr virus, the most common etiologic agent of IM. We also found significant positive associations for number of different domiciles before adulthood and for visits outside the United States; both would be compatible with an increased likelihood among cases of exposures to uncommon viruses or to multiple strains of a common agent. Cases were younger at menarche, increasing the probability of viral exposure after puberty. |
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Authors:
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E A Operskalski; B R Visscher; R M Malmgren; R Detels |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neurology Volume: 39 ISSN: 0028-3878 ISO Abbreviation: Neurology Publication Date: 1989 Jun |
Date Detail:
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Created Date: 1989-07-07 Completed Date: 1989-07-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 825-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, University of Southern California School of Medicine, Los Angeles 90032. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Animals Animals, Domestic Birth Order Family Characteristics Female Housing Humans Infection / complications Menarche Middle Aged Multiple Sclerosis / complications* Socioeconomic Factors Travel |
| Grant Support | |
ID/Acronym/Agency:
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5R01 NS 18317/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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