Document Detail


A case-control study of maternal alcohol consumption and intrauterine growth retardation.
MedLine Citation:
PMID:  11557182     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Heavy maternal drinking during pregnancy causes fetal alcohol syndrome, but whether more moderate alcohol consumption is associated with such adverse pregnancy outcomes as intrauterine growth retardation (IUGR) remains controversial. METHODS: Using data from a case-control study, we examined the association between maternal alcohol consumption and risk for IUGR among 701 case and 336 control infants born during 1993-1995 in Monroe County, New York. RESULTS: Our results provide no evidence of an independent association between moderate maternal alcohol consumption (<14 drinks per week) and risk for IUGR. The risk for IUGR among heavy drinkers (> or =14 drinks per week) around the time of conception was OR = 1.4 (95% CI 0.7-2.6) for IUGR < or = 5th percentile and OR = 1.4 (95% CI 0.7-2.8) for IUGR 5th-10th percentile. For heavy drinkers during the first trimester, the OR was 1.3 (95% CI 0.4-4.5) for IUGR < or = 5th percentile and OR = 1.3 (95% CI 0.4-4.8) for IUGR 5th-10th percentile. CONCLUSIONS: Since IUGR is a heterogeneous outcome with a possible multifactorial origin, further studies are needed to examine the combined effects of alcohol and other environmental and genetic factors on IUGR risk for subgroups of IUGR.
Authors:
Q Yang; B B Witkiewicz; R S Olney; Y Liu; M Davis; M J Khoury; A Correa; J D Erickson
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of epidemiology     Volume:  11     ISSN:  1047-2797     ISO Abbreviation:  Ann Epidemiol     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-09-14     Completed Date:  2001-10-04     Revised Date:  2008-06-23    
Medline Journal Info:
Nlm Unique ID:  9100013     Medline TA:  Ann Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  497-503     Citation Subset:  IM    
Affiliation:
National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, 4770 Buford Highway, MS F-45, Atlanta, GA 30341, USA
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcohol Drinking / adverse effects,  epidemiology*
Case-Control Studies
Female
Fetal Growth Retardation / epidemiology*,  etiology
Humans
Infant, Newborn
Logistic Models
Maternal Exposure* / adverse effects
Pregnancy
Risk

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