Document Detail

A case-control study of hypocalcemia in high-risk neonates: racial, but no seasonal differences.
MedLine Citation:
PMID:  1894877     Owner:  NLM     Status:  MEDLINE    
A role for vitamin D in the defense against falling serum calcium (Ca) concentrations following cord clamping has been suggested. Since race and season are known to affect vitamin D status, we theorized that black race and birth in winter are additional risk factors for neonatal hypocalcemia (NHC). We retrospectively studied 13,462 infants born at University Hospital (Cincinnati, OH) between January 1, 1984 and December 31, 1987. Serum Ca was measured at 24 hours of age routinely in infants with low birth weight (less than 2500 g), preterm delivery (less than 2500 g), preterm delivery (less than 37 weeks), neonatal asphyxia, and diabetic mothers. After exclusion of infants of diabetic mothers (to remove maternal diabetes as a major confounder) and infants with major congenital anomalies, 714 infants remained. In multiple regression analysis, low serum Ca values were significantly associated with low gestational age (p less than 0.01), low Apgar score (p less than 0.01), and white race (p less than 0.01) (R2 = 0.457). Season or month of birth was not significant. In pair-matched analysis controlling for factors other than season, season of birth did not affect serum Ca. In pair-matched analysis controlling for factors other than race, white race was once again a risk factor for hypocalcemia. Thus, low gestational age, low Apgar score, and white race, but not black race and delivery in winter, are risk factors for NHC. We speculate that in our climate and with the prevailing diet in pregnancy, vitamin D deficiency does not appear to play a role in NHC.(ABSTRACT TRUNCATED AT 250 WORDS)
F Mimouni; C P Mimouni; J L Loughead; R C Tsang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the American College of Nutrition     Volume:  10     ISSN:  0731-5724     ISO Abbreviation:  J Am Coll Nutr     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-10-24     Completed Date:  1991-10-24     Revised Date:  2008-06-23    
Medline Journal Info:
Nlm Unique ID:  8215879     Medline TA:  J Am Coll Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  196-9     Citation Subset:  IM    
Department of Pediatrics, University of Cincinnati.
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MeSH Terms
African Americans
Analysis of Variance
Apgar Score
Calcium / blood
Case-Control Studies
European Continental Ancestry Group
Gestational Age
Hypocalcemia / epidemiology*
Infant, Newborn
Multivariate Analysis
Ohio / epidemiology
Regression Analysis
Retrospective Studies
Risk Factors
Grant Support
Reg. No./Substance:

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