| A case-control study of cutaneous signs in adult patients with Marfan disease: Diagnostic value of striae. | |
| | |
MedLine Citation:
|
PMID: 21112669 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
BACKGROUND: Marfan syndrome (MS) (OMIM 154700) has been associated with various skin manifestations. OBJECTIVE: We sought to clarify the value of skin signs in patients with MS. METHODS: This was a case-control study. A total of 61 consecutive patients (median age: 34 years) seen in the French Reference Centre for MS and Related Disorders and with a confirmed diagnosis of MS were paired with 61 age-, sex-, and height-paired control subjects. All had a structured interview and standardized dermatologic examination. The gold standard for MS diagnosis was the Ghent criteria. RESULTS: Striae of any type were significantly (P = .0001) more frequent in patients with MS (92%) than in control subjects (61%), but specificity was low (39%, 95% confidence interval [CI] 27-52). Striae on unusual locations (other than buttock, hip, or thigh) were more frequent in patients with MS (66%) than in control subjects (16%) (P < .0001). This finding had a high specificity (84%, 95% CI 74-93), without notably decreasing sensitivity (66%, 95% CI 54-77). Hypertrophic, large, or atrophic surgical or posttraumatic, frequently hypopigmented or hyperpigmented, scars were present in 46% of patients with MS and 21% of control subjects (P = .007). Sensitivity was 46% (95% CI 34-58) and specificity 79% (95% CI 67-87). Atypical striae in some control subjects could be attributed to intensive practice of sports. LIMITATION: A few control subjects were selected from patients consulting the MS center but without a diagnosis of MS. CONCLUSION: Striae are a good diagnostic criterion for MS, particularly when arising in unusual sites. Other reported skin signs of MS are infrequent. (J Am Acad Dermatol doi:10.1016/j.jaad.2010.01.032.). |
| | |
Authors:
|
Monica Ledoux; Alain Beauchet; Christophe Fermanian; Catherine Boileau; Guillaume Jondeau; Philippe Saiag |
Related Documents
:
|
11182179 - Morphological algebraic models of the tu-wave patterns/in idiopathic long qt syndrome. 20950799 - Changes in the initial slope of the qrs in ischemic patients and normal subjects underg... 6088149 - Fourier amplitude and phase analysis in the clinical evaluation of patients with cardio... 19375919 - Idiopathic hypertrophic cranial pachymeningitis and dural sinus occlusion: two patients... 17584719 - Prevalence of st-elevation in right precordial leads in patients presenting with acute ... 20861419 - Brief report: preoperative abnormal p and qtc dispersion intervals in patients with met... 15480049 - Thoracic manifestation of myeloperoxidase-antineutrophil cytoplasmic antibody (mpo-anca... 3427789 - Hyperprolactinaemia and microadenomas in primary hypothyroidism. 3963949 - Further studies of lipid peroxidation in human paraquat poisoning. |
Publication Detail:
|
Type: Journal Article Date: 2010-11-26 |
Journal Detail:
|
Title: Journal of the American Academy of Dermatology Volume: 64 ISSN: 1097-6787 ISO Abbreviation: J. Am. Acad. Dermatol. Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-01-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7907132 Medline TA: J Am Acad Dermatol Country: United States |
Other Details:
|
Languages: eng Pagination: 290-5 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved. |
Affiliation:
|
Department of Dermatology and Research Unit EA 4339 "Skin, Environment, Cancer," Université Versailles St-Quentin, Ambroise Paré Hospital, Boulogne, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The eDerm online curriculum: A randomized study of effective skin cancer teaching to medical stude...
Next Document: Calcium may preferentially deposit in areas of elastic tissue damage.