| A case-control study of chronic prostatitis/chronic pelvic pain syndrome and colorectal cancer. | |
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MedLine Citation:
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PMID: 22314042 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Study Type - Symptom prevalence (case control) Level of Evidence 2b What's known on the subject? and What does the study add? Associations are well established between intestinal infection/inflammation or inflammatory bowel diseases and colorectal cancer (CRC). Our study found an association between CRC and previously diagnosed chronic prostatitis/chronic pelvic pain syndrome. Patients with CRC had a 1.45-fold higher risk of having a previous diagnosis of chronic prostatitis/chronic pelvic pain syndrome than controls. This phenomenon was found to be more prominent in subjects younger than 60 years. OBJECTIVE: • To estimate the association between chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and colorectal cancer (CRC) using a nationwide population-based data set. PATIENTS AND METHODS: • This case-control study used data sourced from the Taiwan Longitudinal Health Insurance Database. • The cases comprised 2899 patients with CRC and 14 995 randomly selected subjects as controls. • We used conditional logistic regression to examine the association between CRC and previous diagnosis of CP/CPPS. RESULTS: • Of the sampled patients, 531(3.05%) had been diagnosed with CP/CPPS before the index date, with 123 (4.24% of the patients with CRC) coming from the cases and 408 individuals (2.81% of patients without CRC) coming from the controls. • Conditional logistic regression analysis revealed that cases were more likely to have CP/CPPS than controls (odds ratio 1.45, 95% CI 1.17-1.79, P < 0.001) after adjusting for the monthly income, geographic location, urbanization level, hypertension, diabetes, renal disease, obesity and cystic kidney disease. • In subgroup analysis, we found the magnitude of the association to be higher in subjects younger than 60 years (age 40-49, odds ratio 2.01; 95% CI 2.04-3.58 and aged 50-59, 2.40, 95% CI 1.48-3.87, both P < 0.001) than among other age groups. CONCLUSION: • We conclude that CP/CPPS patients are at higher risk for CRC, especially in males under 60 years of age. |
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Authors:
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Shiu-Dong Chung; Joseph J Keller; Herng-Ching Lin |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-7 |
Journal Detail:
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Title: BJU international Volume: - ISSN: 1464-410X ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100886721 Medline TA: BJU Int Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 THE AUTHORS. BJU INTERNATIONAL © 2012 BJU INTERNATIONAL. |
Affiliation:
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Division of Urology, Department of Surgery, Far Eastern Memorial Hospital, Ban Ciao Department of Electronic Engineering, Oriental Institute of Technology, New Taipei Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University School of Health Care Administration School of Medical Laboratory Sciences and Biotechnology, Taipei Medical University, Taipei Department of Urology, Buddhist Tzu Chi General Hospital and College of Medicine, Tzu Chi University, Hualien, Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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