Document Detail

A case-control etiologic study of microcephaly.
MedLine Citation:
PMID:  10955410     Owner:  NLM     Status:  MEDLINE    
We studied the possible environmental factors in the origin of microcephaly by comparing the exposures of 109 infants with isolated microcephaly with those of two matched population controls, in addition to those of 812 patient controls (that is, infants with Down syndrome). Cases and patient controls were selected from the large population-based dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities registered between 1980 and 1996, whereas matched population controls were selected from the national birth registry. We found that there were more females than males among cases with isolated microcephaly. Evaluation of birth weight and gestational age indicated intrauterine growth retardation among microcephalic patients. The use of clotrimazole was higher among mothers in the matched population control group than among mothers of cases. Maternal use of a large dose (about 6 mg per day) of folic acid and more than 50 mg per day of iron during pregnancy was associated with a 40-50% decrease in microcephaly. Thus, the pharmacological doses of folic acid and iron may have some preventive effect against isolated primary microcephaly.
G Abdel-Salam; A E Czeizel
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  11     ISSN:  1044-3983     ISO Abbreviation:  Epidemiology     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2001-01-04     Completed Date:  2001-01-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  571-5     Citation Subset:  IM    
World Health Organization Collaborating Centre for the Community Control of Hereditary Diseases and Department of Human Genetics and Teratology, National Center for Epidemiology, Budapest, Hungary.
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MeSH Terms
Case-Control Studies
Confounding Factors (Epidemiology)
Dietary Supplements
Drug Prescriptions / statistics & numerical data
Hungary / epidemiology
Infant, Newborn
Logistic Models
Microcephaly / epidemiology,  etiology*,  prevention & control
Odds Ratio
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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