| A case of congenital nephrotic syndrome associated with partial deficiency of lecithin cholesterol acyltransferase (LCAT) and hypothyroidism. | |
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MedLine Citation:
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PMID: 6500816 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The case of a 3 year-old boy with congenital nephrotic syndrome is reported, in whom decreased LCAT activity and hypothyroidism were also present. Renal biopsy confirmed a diffuse proliferative glomerulonephritis with a large number of foam cells in the capillary lumen of the glomerulus and the interstitium, which stained positively with acid phosphatase indicating the presence of macrophage with phagocyted lipid vacuole. The histological picture was similar to that of familial LCAT deficiency, but the reported case is one of secondary LCAT deficiency as a result of urinary loss of the enzyme. Replacement therapy with thyroid hormones resulted in improvement in growth and development. |
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Authors:
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M Hiramatsu; S Karashima; S Hattori; I Matsuda; H Maeda |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The International journal of pediatric nephrology Volume: 5 ISSN: 0391-6510 ISO Abbreviation: Int J Pediatr Nephrol Publication Date: 1984 Sep |
Date Detail:
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Created Date: 1985-01-09 Completed Date: 1985-01-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8007162 Medline TA: Int J Pediatr Nephrol Country: ITALY |
Other Details:
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Languages: eng Pagination: 183-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Child, Preschool Humans Hyperlipidemias / etiology Hypolipoproteinemias / etiology* Hypothyroidism / etiology* Lecithin Acyltransferase Deficiency / etiology* Lipoproteins / blood Male Nephrotic Syndrome / complications, congenital* Proteinuria / etiology Serum Albumin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Lipoproteins; 0/Serum Albumin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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