| A case of chronic myeloid leukemia complicated with minimal change nephrotic syndrome. | |
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MedLine Citation:
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PMID: 12624495 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We present a 28-year-old patient with chronic myeloid leukemia (CML) in chronic phase complicated with nephrotic syndrome. The bone marrow cells revealed the presence of Philadelphia chromosome, the cytogenetic hallmark of CML, that results from a balanced, reciprocal translocation between the long arms of chromosomes 9 and 22, t(9;22)(q34;q11). This reciprocal translocation leads to the formation of the BCR/ABL fusion gene, the presence of which was confirmed using the highly sensitive fluorescence in situ hybridization technique. The renal biopsy was compatible with minimal change nephrotic syndrome. To the best of our knowledge, this is the first case of minimal change nephrotic syndrome associated with CML before the administration of any therapy. |
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Authors:
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Rashmi Talwar; S C Dash; Kiran Kucheria |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta haematologica Volume: 109 ISSN: 0001-5792 ISO Abbreviation: Acta Haematol. Publication Date: 2003 |
Date Detail:
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Created Date: 2003-03-07 Completed Date: 2003-03-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0141053 Medline TA: Acta Haematol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 101-3 Citation Subset: IM |
Copyright Information:
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Copyright 2003 S. Karger AG, Basel |
Affiliation:
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Department of Anatomy, All-India Institute of Medical Sciences, New Delhi, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biopsy Chromosomes, Human, Pair 22 Chromosomes, Human, Pair 9 Fusion Proteins, bcr-abl / genetics Humans In Situ Hybridization, Fluorescence Kidney / pathology Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications*, diagnosis, genetics Male Nephrosis, Lipoid / complications*, diagnosis Proteinuria Translocation, Genetic Ultrasonography |
| Chemical | |
Reg. No./Substance:
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0/Fusion Proteins, bcr-abl |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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