| A case of carbamazepine overdose with focal myocarditis. | |
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MedLine Citation:
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PMID: 16820315 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An autopsy case of carbamazepine overdose with focal myocarditis is reported. The decedent was a 33-year-old female with a history of schizophrenia and bipolar disorder, who reportedly took 5-day dose of prescribed medications at around midnight. Although she stayed home following the direction of the physician, she was pronounced dead 8h after the intake. At autopsy she was obese, and her face was slightly swollen. The 420 g heart was free of coronary atherosclerosis, and the myocardium had no obvious scars. Both the left and right lungs were markedly congested and edematous. Strong congestion was also noted in the brain and visceral organs. Microscopic examination disclosed focal infiltration of inflammatory cells, most of which were lymphocytes, into the myocardium. In the toxicological analyses, carbamazepine concentration in the blood was 9.9 microg/ml, and other medications were below the toxic levels. It was considered that under the compromised cardiac function due to myocarditis presumably induced by some prescribed medications, and obesity, the carbamazepine overdose deteriorated her condition by triggering critical arrhythmia or congestive heart failure. |
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Authors:
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Masataka Takamiya; Yasuhiro Aoki; Hisae Niitsu; Kiyoshi Saigusa |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2006-07-03 |
Journal Detail:
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Title: Legal medicine (Tokyo, Japan) Volume: 8 ISSN: 1344-6223 ISO Abbreviation: Leg Med (Tokyo) Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-07-31 Completed Date: 2006-12-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100889186 Medline TA: Leg Med (Tokyo) Country: Ireland |
Other Details:
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Languages: eng Pagination: 243-7 Citation Subset: IM |
Affiliation:
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Department of Legal Medicine, Iwate Medical University School of Medicine, 19-1 Uchimaru Morioka, Iwate 020-8505, Japan. mtakamiy@iwate-med.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antimanic Agents / blood, poisoning* Bipolar Disorder / drug therapy Carbamazepine / blood, poisoning* Female Humans Lymphocytes / pathology Myocarditis / pathology* Myocardium / pathology Obesity / complications Overdose Schizophrenia / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Antimanic Agents; 298-46-4/Carbamazepine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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