Document Detail


A case of c-kit positive high-grade stromal endometrial sarcoma responding to Imatinib Mesylate.
MedLine Citation:
PMID:  16487996     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: High-grade endometrial stromal sarcoma (HGES) is an aggressive disease with dismal prognosis. Surgery is the standard treatment, and radiotherapy seems to reduce local relapse. No other treatment has proved to be useful in the case of non-resectable diseases. CASE: A 41-year-old woman suffering HGES, with positive staining for CD117 (c-kit) and large abdominal and retroperitoneal mass progressing after chemotherapy, was treated with Imatinib Mesylate. After 3 months, objective response was documented and radical surgery performed. Two years after surgical intervention, she is currently free of the disease. CONCLUSION: The response seen with Imatinib should be further investigated in a larger number of cases.
Authors:
Alejandro Salvatierra; Antonio Tarrats; Carmen Gomez; Josep Maria Sastre; Carmen Balaña
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2006-02-20
Journal Detail:
Title:  Gynecologic oncology     Volume:  101     ISSN:  0090-8258     ISO Abbreviation:  Gynecol. Oncol.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-25     Completed Date:  2006-06-27     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0365304     Medline TA:  Gynecol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  545-7     Citation Subset:  IM    
Affiliation:
Medical Oncology Service, Institut Català d'Oncologia, Germans Trias i Pujol, Carretera Canyet s/n, 08916 Badalona, Barcelona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antineoplastic Agents / therapeutic use*
Female
Humans
Piperazines / therapeutic use*
Proto-Oncogene Proteins c-kit / biosynthesis*,  genetics
Pyrimidines / therapeutic use*
Sarcoma, Endometrial Stromal / drug therapy*,  genetics,  metabolism*
Vaginal Neoplasms / drug therapy*,  genetics,  metabolism*
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Piperazines; 0/Pyrimidines; 152459-95-5/imatinib; EC 2.7.10.1/Proto-Oncogene Proteins c-kit

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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