| A case of bronchial carcinoid: diagnosis and follow-up with 111In-DTPA-octreotide. | |
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MedLine Citation:
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PMID: 8624794 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Scintigraphy with radiolabelled analogue of somatostatin is highly sensitive in detecting carcinoid tumors especially if performed with Single Photon Computed Tomography (SPECT). In this report we describe our experience with 111In-DTPA-Octreotide in a female patient affected by a small asymptomatic intrabronchial carcinoid demonstrated by CT scan and bronchial endoscopy performed after recurrent left pneumonias. Planar views and SPECT images, using 111In-DTPA-Octreotide, were collected before and four hours after the first endoscopic laser resection. All groups of SPECT images were positive in the left parahilar region but at a different degree. Scans performed after resection showed a low degree of uptake which was considered to be probably secondary to local swelling; CT scan was negative. Follow up endoscopic biopsy repeated at six months, showed a relapse always in the same site; CT scan of the thorax was again negative. 111In-DTPA-Octreotide images obtained at twelve months were positive always in the left parahilar region, CT scan was negative but another biopsy was not possible. Therefore it was suspected a relapse of the carcinoid which was probably growing only through the bronchial wall without spreading towards the bronchial lumen and/or the lung parenchima. In this occasion, it was also thought that images collected four hours after resection could be positive not only for swelling but for a relapse as well. In every scintigraphic session, SPECT images presented higher quality than planar. This case suggests that 111In-DTPA-Octreotide SPECT is a non-invasive diagnostic technique which could be applied as a follow-up tool especially to patients with no-secreting carcinoid neoplasm and/or with negative or doubtful endoscopic and radiological investigations. |
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Authors:
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P Orsolon; B Bagni; P Basadonna; O Geatti; G Talmassons; U P Guerra |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR) Volume: 39 ISSN: 1125-0135 ISO Abbreviation: Q J Nucl Med Publication Date: 1995 Dec |
Date Detail:
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Created Date: 1996-06-25 Completed Date: 1996-06-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9512274 Medline TA: Q J Nucl Med Country: ITALY |
Other Details:
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Languages: eng Pagination: 311-4 Citation Subset: IM |
Affiliation:
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Institute of Nuclear Medicine, Civil Hospital of Udine, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bronchial Neoplasms / radionuclide imaging* Carcinoid Tumor / radionuclide imaging* Female Humans Octreotide / analogs & derivatives*, diagnostic use Pentetic Acid / analogs & derivatives*, diagnostic use Tomography, Emission-Computed, Single-Photon* |
| Chemical | |
Reg. No./Substance:
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142694-57-3/SDZ 215-811; 67-43-6/Pentetic Acid; 83150-76-9/Octreotide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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