Document Detail

A case of bleomycin-induced acral erythema (AE) with eccrine squamous syringometaplasia (ESS) and summary of reports of AE with ESS in the literature.
MedLine Citation:
PMID:  16361756     Owner:  NLM     Status:  MEDLINE    
Chemotherapy-induced acral erythema (AE) is primarily induced by hydroxyurea, methotrexate, and cytarabine, although there are rare reports of AE induced by combination chemotherapy containing bleomycin. It is thought that the accumulation of chemotherapeutic drugs in eccrine glands may cause eccrine squamous syringometaplasia (ESS), which is characterized by metaplasia and focal necrosis of the epithelium of the eccrine duct. ESS is occasionally detected in conjunction with AE, but such occurrences are relatively uncommon. This is the first report of AE with ESS induced by the administration of bleomycin alone. We also provide a summary of past cases of AE with ESS in the literature.
Hiromi Tsuboi; Kohzoh Yonemoto; Kensei Katsuoka
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The Journal of dermatology     Volume:  32     ISSN:  0385-2407     ISO Abbreviation:  J. Dermatol.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-12-19     Completed Date:  2006-01-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600545     Medline TA:  J Dermatol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  921-5     Citation Subset:  IM    
Department of Dermatology, Kitasato University School of Medicine, Kanagawa, Japan.
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MeSH Terms
Antimetabolites, Antineoplastic / adverse effects*
Bleomycin / adverse effects*
Eccrine Glands / pathology*
Erythema / chemically induced*
Metaplasia / chemically induced
Middle Aged
Necrosis / chemically induced
Reg. No./Substance:
0/Antimetabolites, Antineoplastic; 11056-06-7/Bleomycin

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