| A case of autoimmune thyroiditis and membranoproliferative glomerulonephritis. | |
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MedLine Citation:
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PMID: 18008089 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thyroid hormones play an important role in the growth of the kidney and maintenance of its functions. Prolonged hypothyroidism is known to be accompanied by changes in renal morphology such as thickening of the glomerular and tubular basement membranes as well as increased mesangial matrix. Increased transcapillary leakage of plasma proteins leading to proteinuria and generalized edema is also a known complication of hypothyroidism. In particular, autoimmune thyroiditis is associated with proteinuria. Most previous reports of autoimmune thyroiditis with nephrotic syndrome have demonstrated mixed pathological morphology marked by predominant membranous glomerulopathy. Here we present a patient whose initial presentation with profound hypothyroidism and autoimmune thyroiditis was dominated by nephrotic syndrome secondary to type 1 membranoproliferative glomerulonephritis (MPGN). The association of MPGN and autoimmune thyroiditis is very rare. |
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Authors:
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Sevgi Gurkan; Steven Dikman; M Jeffrey Saland |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2007-11-16 |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 24 ISSN: 0931-041X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-02-04 Completed Date: 2009-04-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 193-7 Citation Subset: IM |
Affiliation:
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Department of Pediatric Nephrology, Mount Sinai School of Medicine, One Gustave Levy Pl, P.O. Box 1664, New York, NY, 10029, USA. Sevgi.gurkan@mssm.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Capillaries
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ultrastructure Female Glomerulonephritis, Membranous / complications*, immunology Graves Disease / complications*, immunology, physiopathology Humans Lymphomatoid Papulosis / complications*, immunology, physiopathology Mesangial Cells / ultrastructure Nephrosis, Lipoid / complications*, immunology, physiopathology Podocytes / ultrastructure Proteinuria / etiology, immunology, physiopathology Thymoma / complications*, immunology, physiopathology Thyroiditis, Autoimmune / complications*, immunology, physiopathology Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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