Document Detail

A case of autoimmune progesterone dermatitis diagnosed by progesterone pessary.
MedLine Citation:
PMID:  21605100     Owner:  NLM     Status:  In-Data-Review    
Autoimmune progesterone dermatitis is a rare, cyclical eruption that occurs in the luteal phase of the menstrual cycle and during pregnancy. Many manifestations have been reported including cyclical eczema, urticaria, erythema multiforme, stomatitis and even anaphylaxis. The condition spontaneously resolves after menopause. As histopathology is non-specific, the diagnosis rests on history with precipitation of the eruption by a progesterone challenge, usually by the intradermal, intramuscular or oral route. We present the case of a 34-year-old woman with a premenstrual papular and eczematous eruption that was exacerbated after pregnancy. Biopsy showed subacute spongiotic dermatitis. To confirm the diagnosis, we used an intravaginal progesterone pessary as a provocation challenge. There was recurrence of the rash 12 h after insertion of the pessary with spontaneous resolution thereafter. We propose that use of a progesterone pessary is an effective tool in the diagnosis of autoimmune progesterone dermatitis.
Katie Le; Glenda Wood
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Australasian journal of dermatology     Volume:  52     ISSN:  1440-0960     ISO Abbreviation:  Australas. J. Dermatol.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0135232     Medline TA:  Australas J Dermatol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  139-41     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. Australasian Journal of Dermatology © 2011 The Australasian College of Dermatologists.
Skin and Cancer Foundation Department of Dermatology, Prince of Wales Hospital, Sydney, New South Wales, Australia.
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