| A case of antiepiligrin cicatricial pemphigoid with nephrotic syndrome. | |
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MedLine Citation:
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PMID: 15187343 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a 71-year-old woman with antiepiligrin cicatricial pemphigoid associated with nephrotic syndrome. She presented with a six-month history of pruritic blisters over her trunk and legs. She also had episodes of recurrent painful oral erosions. A skin biopsy showed a subepidermal bulla, and a direct immunofluorescence (DIF) study revealed linear deposition of IgG and C3 at the basement membrane zone (BMZ). Indirect immunofluorescence (IIF) staining of 1 M NaCl-split skin demonstrated circulating IgG autoantibodies reactive with the dermal side. Immunoprecipitation studies of the patient's serum disclosed IgG autoantibodies directed against a set of polypeptides that corresponded to laminin 5 (beta 3 gamma 2). Based upon the long-standing edema of her legs and her hypoproteinemia, she was diagnosed with nephrotic syndrome. To our knowledge, the association of antiepiligrin cicatricial pemphigoid with nephrotic syndrome has not been reported previously. |
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Authors:
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Yuri Uchino; Takuro Kanekura; Koichiro Takeda; Hidehiko Shimada; Mistuse Inoue; Takashi Hashimoto; Tamotsu Kanzaki |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Journal of dermatology Volume: 31 ISSN: 0385-2407 ISO Abbreviation: J. Dermatol. Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-06-09 Completed Date: 2004-07-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7600545 Medline TA: J Dermatol Country: Japan |
Other Details:
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Languages: eng Pagination: 228-31 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Kagoshima University Faculty of Medicine, Kagoshima, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Autoantibodies / immunology* Biopsy, Needle Cell Adhesion Molecules / immunology* Female Follow-Up Studies Humans Immunoglobulin G / analysis, immunology Immunohistochemistry Japan Nephrotic Syndrome / complications*, diagnosis, drug therapy, immunology Pemphigoid, Benign Mucous Membrane / complications*, drug therapy, immunology, pathology* Prednisone / therapeutic use Risk Assessment Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Cell Adhesion Molecules; 0/Immunoglobulin G; 0/kalinin; 53-03-2/Prednisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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