Document Detail


A case of anti-epiligrin cicatricial pemphigoid associated with lung carcinoma and severe laryngeal stenosis: review of Japanese cases and evaluation of risk for internal malignancy.
MedLine Citation:
PMID:  14739497     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 68-year-old Japanese male with a five-year-history of lung carcinoma showed recurrent blisters and erosions on the oral and genital mucosae and the skin. The patient complained of dyspnea due to severe laryngeal stenosis and underwent a tracheostomy. A skin biopsy specimen showed a subepidermal blister and linear deposits of IgG and C3 at the basement membrane zone of the epidermis. Indirect immunofluorescence examination demonstrated circulating IgG anti-basement membrane zone autoantibodies that reacted to epiligrin on immunoblotting. Based on a diagnosis of anti-epiligrin cicatricial pemphigoid, he was treated with prednisolone, minocycline hydrochloride and nicotinamide. Although no new skin lesions appeared, he died of lung carcinoma five months after the tracheostomy. A review of reported cases with anti-epiligrin cicatricial pemphigoid in Japan disclosed that 5 of 16 cases (31.2%) were complicated by internal malignancies.
Authors:
Satoko Matsushima; Yuji Horiguchi; Tetsuya Honda; Shinobu Fujii; Takayuki Okano; Masahiro Tanabe; Toshiaki Wakayama; Takashi Hashimoto; Kim B Yancey
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The Journal of dermatology     Volume:  31     ISSN:  0385-2407     ISO Abbreviation:  J. Dermatol.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-23     Completed Date:  2004-05-11     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7600545     Medline TA:  J Dermatol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  10-5     Citation Subset:  IM    
Affiliation:
Departments of Dermatology, Osaka Red Cross Hospital, Ten'noji-ku, Osaka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Autoantibodies / immunology*
Biopsy, Needle
Cell Adhesion Molecules / analysis,  immunology*
Drug Therapy, Combination
Fatal Outcome
Humans
Immunohistochemistry
Laryngoscopy / methods
Laryngostenosis / complications,  diagnosis*,  surgery
Lung Neoplasms / complications*,  pathology,  therapy
Male
Pemphigoid, Benign Mucous Membrane / complications,  drug therapy,  immunology*,  pathology*
Risk Assessment
Severity of Illness Index
Tracheostomy / methods
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Cell Adhesion Molecules; 0/kalinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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