Document Detail

A case of acute renal failure in a patient recently treated with clozapine and a review of previously reported cases.
MedLine Citation:
PMID:  21977363     Owner:  NLM     Status:  In-Data-Review    
Clozapine has been reported to cause acute renal failure due to acute interstitial nephritis. We discuss a case of clozapine-induced acute renal failure and compare it to 7 other cases reported in the literature. We review the signs and symptoms of the hypersensitivity response, such as fever and eosinophilia, caused by clozapine and make recommendations for early detection. Early detection and prompt discontinuation of clozapine can prevent renal damage, as can the avoidance of other nephrotoxic drugs like antibiotics.
J Daniel Kanofsky; Mary E Woesner; Alexander Z Harris; James P Kelleher; Karen Gittens; Elina Jerschow
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The primary care companion to CNS disorders     Volume:  13     ISSN:  2155-7780     ISO Abbreviation:  Prim Care Companion CNS Disord     Publication Date:  2011  
Date Detail:
Created Date:  2011-10-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101547532     Medline TA:  Prim Care Companion CNS Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  -    
Bronx Psychiatric Center (Drs Kanofsky, Woesner, and Gittens); Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx (Drs Kanofsky and Woesner); Department of Psychiatry, Weill Cornell Medical College, New York (Dr Harris); New York Medical College, St Vincent's Hospital Westchester, Harrison (Dr Kelleher); and Department of Allergy and Immunology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx (Dr Jerschow), New York.
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