Document Detail

A case of acute promyelocytic leukemia complicated with severe esophageal stenosis caused by aclacinomycin A
MedLine Citation:
PMID:  3861136     Owner:  NLM     Status:  MEDLINE    
Aclacinomycin A (ACM) is different from other anthracycline antibiotics in its antitumor activity and clinical effect. We report a case of acute promyelocytic leukemia complicated with severe esophageal ulcer by BH-AC . AMP therapy. The patient was 24 years old. In 1983, he achieved complete remission with BH-AC . DMP therapy but we confirmed relapse in April, 1984. ACM caused nausea, vomiting, diarrhea, alimentary tract bleeding and sore throat, together with a complication of esophageal stenosis. In about half of 10 cases receiving BH-AC . AMP therapy in our hospital, we noticed severe bleeding in the urinary treat, genital organs and alimentary tract. Care should therefore be taken with regard to mucosal injury when ACM therapy is used.
T Kataoka; H Takeyama; E Watanabe; K Yano
Publication Detail:
Type:  Case Reports; English Abstract; Journal Article    
Journal Detail:
Title:  Gan to kagaku ryoho. Cancer & chemotherapy     Volume:  12     ISSN:  0385-0684     ISO Abbreviation:  Gan To Kagaku Ryoho     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1985-09-06     Completed Date:  1985-09-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7810034     Medline TA:  Gan To Kagaku Ryoho     Country:  JAPAN    
Other Details:
Languages:  jpn     Pagination:  1686-9     Citation Subset:  IM    
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MeSH Terms
6-Mercaptopurine / administration & dosage
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Cytarabine / administration & dosage,  analogs & derivatives
Esophageal Stenosis / chemically induced*
Leukemia, Lymphoid / complications,  drug therapy*
Naphthacenes / adverse effects
Prednisolone / administration & dosage
Reg. No./Substance:
0/Naphthacenes; 147-94-4/Cytarabine; 50-24-8/Prednisolone; 50-44-2/6-Mercaptopurine; 57576-44-0/Aclarubicin

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