| A case of acute encephalitis with refractory, repetitive partial seizures, presenting autoantibody to glutamate receptor Gluepsilon2. | |
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MedLine Citation:
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PMID: 16198211 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An 11-year-old male was admitted to our hospital because of high-grade fever, repetitive seizures, and prolonged impairment of consciousness (Glasgow coma scale E1, M5, V1). His seizures were repetitive complex partial seizures that expanded from the unilateral face to the corresponding side of the body. He sometimes developed secondary generalized seizures. While most seizures lasted 1 or 2 min, intractable seizures also frequently (about 5 times/h) occurred. We diagnosed him as encephalitis/encephalopathy, and treated him with artificial respiration, thiamylal sodium, mild hypothermia therapy, steroid pulse therapy, massive gamma-globulin therapy, etc. Afterwards, he had sequelae, such as post-encephalitic epilepsy (same seizures continued to recur), hyperkinesia, impairment of immediate memory, change in character (he became sunny and obstinate), dysgraphia, and mild atrophy of the hippocampus, amygdala, and cerebrum. However, he could still attend a general junior high school. He was diagnosed as acute encephalitis with refractory, repetitive partial seizures (AERRPS). In this case, he was positive for autoantibody to glutamate receptor Gluepsilon2 IgG or IgM in an examination of blood and spinal fluid, and we presumed that this may have influenced his sequelae. In this case, a combination of mild hypothermia therapy, steroid pulse therapy, and massive gamma-globulin therapy was effective. |
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Authors:
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Hiromichi Ito; Kenji Mori; Yoshihiro Toda; Mayumi Sugimoto; Yukitoshi Takahashi; Yasuhiro Kuroda |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Brain & development Volume: 27 ISSN: 0387-7604 ISO Abbreviation: Brain Dev. Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-10-03 Completed Date: 2005-12-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7909235 Medline TA: Brain Dev Country: Netherlands |
Other Details:
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Languages: eng Pagination: 531-4 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15, Kuramoto-Cho, Tokushima 770-8503, Japan. moriken@clin.med.tokushima-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Autoantibodies
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blood,
immunology* Child Electroencephalography Encephalitis* / diagnosis, immunology, physiopathology, therapy Humans Male Receptors, N-Methyl-D-Aspartate / immunology* Seizures* gamma-Globulins / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/NR2B NMDA receptor; 0/Receptors, N-Methyl-D-Aspartate; 0/gamma-Globulins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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