Document Detail

A case of acute encephalitis with refractory, repetitive partial seizures, presenting autoantibody to glutamate receptor Gluepsilon2.
MedLine Citation:
PMID:  16198211     Owner:  NLM     Status:  MEDLINE    
An 11-year-old male was admitted to our hospital because of high-grade fever, repetitive seizures, and prolonged impairment of consciousness (Glasgow coma scale E1, M5, V1). His seizures were repetitive complex partial seizures that expanded from the unilateral face to the corresponding side of the body. He sometimes developed secondary generalized seizures. While most seizures lasted 1 or 2 min, intractable seizures also frequently (about 5 times/h) occurred. We diagnosed him as encephalitis/encephalopathy, and treated him with artificial respiration, thiamylal sodium, mild hypothermia therapy, steroid pulse therapy, massive gamma-globulin therapy, etc. Afterwards, he had sequelae, such as post-encephalitic epilepsy (same seizures continued to recur), hyperkinesia, impairment of immediate memory, change in character (he became sunny and obstinate), dysgraphia, and mild atrophy of the hippocampus, amygdala, and cerebrum. However, he could still attend a general junior high school. He was diagnosed as acute encephalitis with refractory, repetitive partial seizures (AERRPS). In this case, he was positive for autoantibody to glutamate receptor Gluepsilon2 IgG or IgM in an examination of blood and spinal fluid, and we presumed that this may have influenced his sequelae. In this case, a combination of mild hypothermia therapy, steroid pulse therapy, and massive gamma-globulin therapy was effective.
Hiromichi Ito; Kenji Mori; Yoshihiro Toda; Mayumi Sugimoto; Yukitoshi Takahashi; Yasuhiro Kuroda
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Brain & development     Volume:  27     ISSN:  0387-7604     ISO Abbreviation:  Brain Dev.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-03     Completed Date:  2005-12-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909235     Medline TA:  Brain Dev     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  531-4     Citation Subset:  IM    
Department of Pediatrics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15, Kuramoto-Cho, Tokushima 770-8503, Japan.
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MeSH Terms
Autoantibodies / blood,  immunology*
Encephalitis* / diagnosis,  immunology,  physiopathology,  therapy
Receptors, N-Methyl-D-Aspartate / immunology*
gamma-Globulins / therapeutic use
Reg. No./Substance:
0/Autoantibodies; 0/NR2B NMDA receptor; 0/Receptors, N-Methyl-D-Aspartate; 0/gamma-Globulins

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