| A case of acquired hemophilia A with massive hemothorax. | |
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MedLine Citation:
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PMID: 22086484 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Acquired hemophilia A (AHA) is an uncommon but potentially life-threatening hemorrhagic disorder caused by the development of an inhibitor against coagulation factor VIII (FVIII). AHA is very rare, affecting approximately 1 in 1 million individuals. However, the incidence may actually be higher, because diagnosis is difficult and the disease can be overlooked. We report a case of an 80-year-old man who presented with sudden onset of severe hemothorax. The patient was diagnosed with presumed AHA based on acute onset of bleeding symptoms and unexplained isolated prolonged activated partial thromboplastin time. Diagnosis was definitely established by demonstrating a decrease in FVIII activity, presence of FVIII inhibitor activity, and normal von Willebrand factor. The patient was successfully treated with recombinant activated coagulation factor VII and transcatheter artery embolization of the intercostal arteries. |
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Authors:
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Tomihiro Fukushima; Takeshi Mikane; Daisuke Ono; Satoru Oku; Hiroyuki Kobayashi; Yoko Watanabe; Etsu Iwasaki; Mizue Ishii; Hiroaki Tokioka |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-16 |
Journal Detail:
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Title: Journal of anesthesia Volume: - ISSN: 1438-8359 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8905667 Medline TA: J Anesth Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Anesthesiology, Okayama Red Cross Hospital, 2-1-1 Aoe, Kita-ku, Okayama, Okayama, 700-8607, Japan, tomihiro.fukushima@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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