| A case of Weber-Christian disease associated with myelodysplastic syndrome. | |
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MedLine Citation:
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PMID: 17028810 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We report the case of a 73-year-old man with myelodysplastic syndrome (MDS) who developed Weber-Christian disease (WCD). Bone marrow aspirates showed refractory anemia with abnormal karyotypes such as trisomy 8, trisomy 8 and 14, and trisomy 8, 9, and 14. The patient had intermittent fever associated with multiple tender erythematous nodules on the skin. A biopsy sample taken from a nodule revealed focal subcutaneous infiltration of neutrophils and necrotizing fat tissue. We diagnosed the patient as having lobular panniculitis associated with myelodysplastic syndrome. The serum levels of soluble interleukin-2 (IL-2) receptor, interferon-Gamma, IL-1-Beta, IL-6 and tumor necrosis factor-Alpha were elevated in the active state but returned to normal after prednisolone therapy. This finding appears to implicate a T-cell immune response in the pathogenesis of Weber-Christian disease. |
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Authors:
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Nobumasa Hojo; Hitoshi Hasegawa; Kikue Iwamasa; Satoko Hojo; Shigeru Fujita |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Modern rheumatology / the Japan Rheumatism Association Volume: 14 ISSN: 1439-7595 ISO Abbreviation: Mod Rheumatol Publication Date: 2004 |
Date Detail:
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Created Date: 2006-10-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100959226 Medline TA: Mod Rheumatol Country: Japan |
Other Details:
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Languages: eng Pagination: 73-6 Citation Subset: - |
Affiliation:
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First Department of Internal Medicine, Ehime University School of Medicine, Shigenobu, Onsen-gun, Ehime, 791-0295, Japan, hitoshih@m.ehime-u.ac.jp. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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