Document Detail


A case of Sturge-Weber syndrome with symptomatic hemiplegic migraine: clinical and multimodality imaging data during a prolonged attack.
MedLine Citation:
PMID:  19733861     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hemiplegic migraine (HM) in the setting of Sturge-Weber syndrome (SWS) has been previously described. Here, we report clinical and multimodal imaging data on a 21-year-old man with SWS and HM, who presented during an acute HM attack with a dense left-hemispheric syndrome (expressive aphasia and right sensorimotor hemiplegia), lasting for more than 10 days. Repeated EEGs were without evidence of status epilepticus. Consistent with previous findings in prolonged migraine aura, perfusion computed tomography demonstrated left-hemispheric hyperperfusion on day 7. 18F-FDG positron emission tomography (day 7) revealed left-hemispheric hypermetabolism. After 14 days, the patient was symptom-free and discharged home. Follow-up after 30 days showed normal neurological status. Our observation confirms and reinforces the comorbidity of SWS and HM and shows that prolonged HM attacks are associated with complex changes of both cerebral perfusion and glucose metabolism. A pathophysiological model explaining both the association between SWS/HM and the observed imaging changes is presented.
Authors:
Tobias Freilinger; Nils Peters; Jan R?mi; Jennifer Linn; Marcus Hacker; Andreas Straube; Thomas Pfefferkorn
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-09-06
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  287     ISSN:  1878-5883     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-09     Completed Date:  2010-02-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  271-4     Citation Subset:  IM    
Affiliation:
Department of Neurology, Ludwig-Maximilians-University, Munich, Germany. tobias.freilinger@med.uni-muenchen.de
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MeSH Terms
Descriptor/Qualifier:
Brain / metabolism*,  physiopathology,  radionuclide imaging*
Cerebrovascular Circulation / physiology
Comorbidity
Diagnosis, Differential
Energy Metabolism / physiology
Fluorodeoxyglucose F18
Glucose / metabolism
Humans
Male
Migraine with Aura / complications*,  physiopathology,  radionuclide imaging*
Models, Neurological
Positron-Emission Tomography
Sturge-Weber Syndrome / complications*,  physiopathology,  radionuclide imaging*
Tomography, X-Ray Computed
Young Adult
Chemical
Reg. No./Substance:
50-99-7/Glucose; 63503-12-8/Fluorodeoxyglucose F18

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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