Document Detail

A case of Serratia granuloma in the soft tissue around the left kidney: a role of PTHrP in the formation of Serratia granuloma.
MedLine Citation:
PMID:  20140475     Owner:  NLM     Status:  MEDLINE    
Serratia marcescens is an ubiquitous, saprophytic gram-negative bacillus that is associated with infections such as bacteremia, pneumonia and osteomyelitis. However, it has not been known to form granulomas. A 72-year-old man with a history of tricuspidal insufficiency, mitral insufficiency and ureterolithiasis presented with lumbago on the left side. He was admitted to our hospital, where abscess formation in the subcapsular space and perirenal fat space of the left kidney, and left renal calculi were identified by computed tomography of the abdomen. As infection and/or a tumor were suspected, nephrectomy was performed. The histopathological findings in the resected kidney indicated severe infiltration by inflammatory cells with lymphoid follicles in the interstitium, and the proliferation of mesangial cells and matrix in glomerulus. Furthermore, giant cell granulomas were observed in the soft tissue around the kidney. As an aerobic culture of the abscess from the granulomas only produced Serratia marcescens, these granulomas were diagnosed as Serratia marcescens granulomas. In addition, expressions of PTHrP and PTH/PTHrP-receptor were observed in the giant cells in Serratia granuloma, which suggested that PTHrP might be involved in giant cell formation in Serratia granuloma by autocrine and/or paracrine mechanisms.
Yuko Yoshihiro; Yoshifumi Soejima; Keisuke Taniguchi; Kenji Makino; Shinji Naito
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-02-06
Journal Detail:
Title:  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy     Volume:  16     ISSN:  1437-7780     ISO Abbreviation:  J. Infect. Chemother.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-05     Completed Date:  2010-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9608375     Medline TA:  J Infect Chemother     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  126-30     Citation Subset:  IM    
Department of Respiratory Medicine, National Hospital Organization Ureshino Medical Center, Ureshino, Japan.
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MeSH Terms
Granuloma / metabolism,  microbiology*,  pathology
Kidney Diseases / metabolism,  microbiology*,  pathology
Parathyroid Hormone-Related Protein / biosynthesis*
Receptor, Parathyroid Hormone, Type 1 / biosynthesis
Serratia / isolation & purification*
Serratia Infections / metabolism,  microbiology*,  pathology
Soft Tissue Infections / metabolism,  microbiology*,  pathology
Tomography, X-Ray Computed
Reg. No./Substance:
0/Parathyroid Hormone-Related Protein; 0/Receptor, Parathyroid Hormone, Type 1

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