Document Detail

A case of SAPHO (synovitis-acne-pustulosis-hyperostosis-osteomyelitis) syndrome in which [18F]fluorodeoxyglucose positron emission tomography was useful for differentiating from multiple metastatic bone tumors.
MedLine Citation:
PMID:  17278026     Owner:  NLM     Status:  MEDLINE    
We report the case of a 50-year-old Japanese woman with SAPHO (synovitis-acne-pustulosis-hyperostosis-osteomyelitis) syndrome. Radiographs showed osteosclerosis of the cervical and lumbar vertebrae, as well as osteosclerosis and osteolysis of the right femoral neck, resembling multiple metastatic bony lesions. Arriving at a diagnosis required hematological and imaging tests. Whole-body bone scintigraphy identified diffuse uptake from the lower cervical vertebrae to the lumbar vertebrae and marked uptake in the right femoral neck. However, with [(18)F]fluorodeoxyglucose positron emission tomography ([(18)F]FDG-PET) scanning, abnormal [(18)F]FDG uptake was not detected in cervical and lumbar spine, or in the femoral neck. Bone biopsy showed signs of chronic nonspecific inflammation, rather than tumor or infection. Based on these findings, the patient was diagnosed with SAPHO syndrome unaccompanied by skin lesions, and administration of non-steroidal anti-inflammatory drugs provided pain relief.
Kimihiko Takeuchi; Masatoshi Matsusita; Kenji Takagishi
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2007-02-20
Journal Detail:
Title:  Modern rheumatology / the Japan Rheumatism Association     Volume:  17     ISSN:  1439-7595     ISO Abbreviation:  Mod Rheumatol     Publication Date:  2007  
Date Detail:
Created Date:  2007-02-05     Completed Date:  2007-04-27     Revised Date:  2007-08-01    
Medline Journal Info:
Nlm Unique ID:  100959226     Medline TA:  Mod Rheumatol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  67-71     Citation Subset:  IM    
Maebashi Red Cross Hospital, 3-21-36 Asahi-machi, Maebashi 371-0014, Japan.
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MeSH Terms
Acquired Hyperostosis Syndrome / radionuclide imaging*
Bone Neoplasms / radionuclide imaging*,  secondary
Diagnosis, Differential
Fluorodeoxyglucose F18 / diagnostic use
Inflammation / radionuclide imaging
Middle Aged
Osteolysis / radiography
Osteosclerosis / radiography
Positron-Emission Tomography
Radiopharmaceuticals / diagnostic use
Reg. No./Substance:
0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18

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