| A case of Noonan syndrome and Whipple's disease in the same patient. | |
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MedLine Citation:
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PMID: 19322929 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report the first known case of both Noonan syndrome and Whipple's disease occurring in the same patient. A 36-year-old female with history of Noonan syndrome developed fatigue, anorexia, arthritis of the knees and hands with a diffuse hyperpigmented rash, night sweats, and an unintentional fifteen pound weight loss over 4 mo. Small bowel enteroscopy demonstrated mild edematous yellowish mucosa without friability. Random small bowel biopsies revealed extensive periodic acid-Schiff positive material within the foamy macrophages. She was treated with a 12 mo course of trimethoprim-sulfamethoxazole DS with clinical improvement to baseline status. |
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Authors:
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Sundip S Karsan; Hetal A Karsan; Anand S Karsan; James Ian McMillen |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 15 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-03-26 Completed Date: 2009-05-14 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 1524-7 Citation Subset: IM |
Affiliation:
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Cedars-Sinai Medical Center, 8700 Beverly Blvd, Room 5512, Los Angeles, California, CA 90048, USA. sundip.karsan@cshs.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Infective Agents / therapeutic use Biopsy Female Humans Macrophages / pathology Noonan Syndrome / complications*, pathology Sulfamethoxazole / therapeutic use* Treatment Outcome Trimethoprim / therapeutic use* Whipple Disease / complications*, drug therapy, pathology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 723-46-6/Sulfamethoxazole; 738-70-5/Trimethoprim |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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