Document Detail

The case of the Marquis de Causan (1804): an early account of visual loss associated with spinal cord inflammation.
MedLine Citation:
PMID:  22237820     Owner:  NLM     Status:  Publisher    
The recent discovery of disease specific and pathogenic autoantibodies in neuromyelitis optica (NMO, Devic's disease) has revived the interest in this intriguing yet often devastating condition. While the history of classic multiple sclerosis has been studied extensively, only very little is known so far about the early history of NMO. Here we discuss a now forgotten report by the famous French anatomist and pathologist Antoine Portal (1742-1832), first physician to Louis XVIII and founding and lifelong president of the Académie Nationale de Médecine. Portals report, which fascinated some of the most renowned 19th century pioneers in the field of neurology but fell in oblivion later, represents the first account of visual loss in a patient with spinal cord inflammation but no brain pathology reported in the Western literature known so far--published more than 60 years prior to Thomas Clifford Allbutt's much cited note on a patient with myelitis and a "sympathetic eye disorder".
S Jarius; B Wildemann
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-12
Journal Detail:
Title:  Journal of neurology     Volume:  -     ISSN:  1432-1459     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0423161     Medline TA:  J Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Division of Molecular Neuroimmunology, Department of Neurology, Otto Meyerhof Center, University of Heidelberg, Im Neuenheimer Feld 350, 69120, Heidelberg, Germany,
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