| A case of HIV-associated cerebral histoplasmosis successfully treated with fluconazole. | |
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MedLine Citation:
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PMID: 10534189 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clinically apparent involvement of the central nervous system is a rare event in cases of disseminated histoplasmosis, even in HIV-infected persons. Despite therapy with amphotericin B, mortality remains very high. Reported here is the case of an HIV-infected patient with a 3-month history of fever, cough, weight loss and miliary lung infiltrates. Four weeks after initiation of tuberculostatic therapy, high-grade fever, neurological symptoms, personality changes and respiratory deterioration occurred. Magnetic resonance imaging of the brain showed multiple mass lesions, and a chest radiograph revealed worsening of pulmonary infiltrates. Methenamine silver staining of a lung biopsy specimen demonstrated Histoplasma capsulatum. Subsequently, this pathogen was cultured from lavage fluid. Following high-dose intravenous fluconazole therapy (800 mg once daily), the patient's condition improved markedly within 10 days, followed by an almost complete resolution of pulmonary and cerebral mass lesions. This is believed to be the first documented case of rapid improvement of disseminated histoplasmosis with central nervous system involvement in an HIV-infected patient upon induction of therapy with fluconazole. |
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Authors:
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S Knapp; M Turnherr; G Dekan; B Willinger; G Stingl; A Rieger |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology Volume: 18 ISSN: 0934-9723 ISO Abbreviation: Eur. J. Clin. Microbiol. Infect. Dis. Publication Date: 1999 Sep |
Date Detail:
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Created Date: 1999-11-17 Completed Date: 1999-11-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8804297 Medline TA: Eur J Clin Microbiol Infect Dis Country: GERMANY |
Other Details:
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Languages: eng Pagination: 658-61 Citation Subset: IM; X |
Affiliation:
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Department of Internal Medicine I, University of Vienna Medical School, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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AIDS-Related Opportunistic Infections
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drug therapy* Adult Antifungal Agents / therapeutic use* Brain Diseases / drug therapy* Central Nervous System Fungal Infections / drug therapy* Fluconazole / therapeutic use* Histoplasmosis / drug therapy* Humans Male |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 86386-73-4/Fluconazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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