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A case of Cushing's syndrome in pregnancy.
MedLine Citation:
PMID:  21528482     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Cushing's syndrome (also known as hypercortisolemia) is rare in pregnant women due to the menstrual disturbances and infertility in women with hypercortisolism. A diagnosis of pathological hypercortisolism in pregnant women is often difficult as some symptoms of the disease may be associated with a complicated pregnancy. Hypercortisolemia leads to serious complications for mother and foetus, and is associated with premature labour and high foetal mortality. Hormonal and radiological diagnostics in pregnancy are limited. The results of hormonal measurements and dynamic tests are difficult to interpret due to the physiological changes in the hypothalamo-pituitaryadrenal axis connected with pregnancy. The optimal time and method of treatment should be chosen cautiously case by case because of the possibility of maternal and foetal complications. In this paper, we present a case of Cushing's syndrome secondary to adrenal adenoma in which the diagnosis was made in the 22(nd) week of pregnancy. Due to the advanced gestational status and mild symptoms of hypercortisolism, only symptomatic treatment was introduced. The patient was under continuous obstetric and endocrinological care. At 35 weeks of gestation, the pregnancy was terminated by emergency caesarean section because of premature detachment of the placenta. A male infant weighing 2,450 g was delivered; neither adrenal insufficiency in the child nor hypercortisolemia complications in the mother were observed. (Pol J Endocrinol 2011; 62 (2): 181-185).
Authors:
Grażyna Bednarek-Tupikowska; Eliza Kubicka; Teresa Sicińska-Werner; Anna Kazimierczak; Jacek Winowski; Małgorzata Tupikowska; Maria Janczyszyn; Marek Bolanowski
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Endokrynologia Polska     Volume:  62     ISSN:  0423-104X     ISO Abbreviation:  Endokrynol Pol     Publication Date:    2011 Mar-Apr
Date Detail:
Created Date:  2011-04-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370674     Medline TA:  Endokrynol Pol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  181-5     Citation Subset:  IM    
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