| A case of Crow-Fukase syndrome with elevated soluble interleukin-6 receptor in cerebrospinal fluid. Response to double-filtration plasmapheresis and corticosteroids. | |
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MedLine Citation:
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PMID: 7484019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report the case of a 33-year-old Japanese male who presented with thrombocytosis, lower limb edema, severe polyneuropathy with elevated cerebrospinal fluid (CSF) protein level and serum IgA lambda monoclonal component, fulfilling the manifestations of Crow-Fukase syndrome. A high level of soluble interleukin-6 receptor in the CSF was also found, which fluctuated in parallel with the clinical course. Initial treatment with double-filtration plasmapheresis (DFPP) reduced the serum IgA paraprotein level with improvement of the sensory component of the polyneuropathy and decrease of soluble interleukin-6 receptor in the CSF. The remaining clinical features waned off after steroid treatment. The possible role of interleukin-6 in the pathogenesis of the Crow-Fukase syndrome and the utility of DFPP treatment are discussed. |
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Authors:
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T Atsumi; K Kato; S Kurosawa; M Abe; A Fujisaku |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Acta haematologica Volume: 94 ISSN: 0001-5792 ISO Abbreviation: Acta Haematol. Publication Date: 1995 |
Date Detail:
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Created Date: 1995-12-01 Completed Date: 1995-12-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0141053 Medline TA: Acta Haematol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 90-4 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Tomakomai City Hospital, Hokkaido, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Combined Modality Therapy Glucocorticoids / therapeutic use Humans Interleukin-6 / cerebrospinal fluid*, metabolism Male POEMS Syndrome / cerebrospinal fluid*, metabolism, therapy* Plasmapheresis Receptors, Interleukin / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 0/Interleukin-6; 0/Receptors, Interleukin |
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