| A case of Castleman's disease complicated with nephrotic syndrome due to glomerulopathy mimicking membranoproliferative glomerulonephritis. | |
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MedLine Citation:
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PMID: 18552583 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Castleman's disease is a rare atypical lymphoproliferative disorder. Renal manifestations, such as proteinuria, hematuria, and renal dysfunction, are common in Castleman's disease; however, a nephrotic syndrome rarely occurs. We have encountered an unusual case of Castleman's disease of the plasma cell type characterized by nephrotic syndrome because of glomerulopathy mimicking membranoproliferative glomerulonephritis. Our patient showed higher levels of circulating cytokines (interleukin-6/vascular endothelial cell-derived growth factor), the glomerular lesions not associated with immunocomplex deposition, and the resolution of nephrotic syndrome after successful corticosteroids therapy resulting in a decline in cytokines levels, thereby implicating a cytokine-induced glomerular cell injury/activation as a possible cause of the glomerular pathological changes in this case. |
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Authors:
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Toshiro Sugimoto; Jun Ito; Naoko Takeda; Ippei Gasyu; Tsutomu Okazaki; Masayoshi Sakaguchi; Norihisa Osawa; Yuki Tanaka; Kazumasa Oka; Takashi Uzu; Atsunori Kashiwagi |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The American journal of the medical sciences Volume: 335 ISSN: 0002-9629 ISO Abbreviation: Am. J. Med. Sci. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-06-16 Completed Date: 2008-07-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370506 Medline TA: Am J Med Sci Country: United States |
Other Details:
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Languages: eng Pagination: 495-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Shiga University of Medical Science, Seta, Otsu, Shiga 5202192, Japan. toshiro@belle.shiga-med.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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therapeutic use Diagnosis, Differential Female Giant Lymph Node Hyperplasia / complications*, drug therapy, pathology Glomerulonephritis / complications, drug therapy, pathology Glomerulonephritis, Membranoproliferative / complications, drug therapy, pathology* Humans Kidney Glomerulus / ultrastructure* Middle Aged Nephrotic Syndrome / complications*, drug therapy, pathology Prednisolone / therapeutic use Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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