Document Detail

A case of Albright's syndrome treated with calcitonin.
MedLine Citation:
PMID:  474095     Owner:  NLM     Status:  MEDLINE    
A 23-year-old woman with Albright's syndrome (polyostotic fibrous dysplasia of bone, precocious puberty and irregular cutaneous pigmentations) had sustained multiple fractures and was grossly disabled. Evaluation disclosed markedly raised serum alkaline phosphatases and a high urinary excretion of hydroxyproline, suggesting an accelerated bone turnover, while calcium metabolism was virtually undisturbed. During 12 months therapy with calcitonin, however, no apparent benefit was recorded and there was no evidence of any significant metabolic effects of the treatment. Initial discomfort with nausea and vomiting disappeared after dose reduction whereas diffuse bone and muscle pain, which gradually increased after a few months treatment, did not subside until after cessation of the therapy.
A Hjelmstedt; S Ljunghall
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta orthopaedica Scandinavica     Volume:  50     ISSN:  0001-6470     ISO Abbreviation:  Acta Orthop Scand     Publication Date:  1979 Jun 
Date Detail:
Created Date:  1979-10-24     Completed Date:  1979-10-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370352     Medline TA:  Acta Orthop Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  251-3     Citation Subset:  IM    
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MeSH Terms
Calcitonin / administration & dosage,  adverse effects,  therapeutic use*
Fibrous Dysplasia of Bone / drug therapy*
Fibrous Dysplasia, Polyostotic / drug therapy*
Reg. No./Substance:

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