| A case of AA amyloidosis associated with rheumatoid arthritis effectively treated with Infliximab. | |
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MedLine Citation:
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PMID: 18496698 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report the case of a 55-year-old Japanese woman with reactive AA amyloidosis associated with rheumatoid arthritis, in which inflammatory disease was completely suppressed with infliximab. Nephrotic syndrome was observed and renal biopsy specimens revealed amyloidosis deposits. Treatment with infliximab normalized the serum amyloid A (SAA) protein level, and subsequently nephritic syndrome disappeared and her creatinine clearance improved. Serial gastrointestinal biopsy specimens showed marked lasting regression of amyloid deposits. Thus treatment with infliximab represents an important therapeutic strategy for AA amyloidosis associated with RA. |
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Authors:
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Takeshi Kuroda; Yasuhiro Otaki; Hiroe Sato; Takeo Fujimura; Takeshi Nakatsue; Syuichi Murakami; Minoru Sakatsume; Masaaki Nakano; Fumitake Gejyo |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-05-22 |
Journal Detail:
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Title: Rheumatology international Volume: 28 ISSN: 0172-8172 ISO Abbreviation: Rheumatol. Int. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-12 Completed Date: 2009-03-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8206885 Medline TA: Rheumatol Int Country: Germany |
Other Details:
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Languages: eng Pagination: 1155-9 Citation Subset: IM |
Affiliation:
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Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-Dori, Niigata City 951-8510, Japan. kurodat@med.niigata-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amyloidosis
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drug therapy*,
etiology*,
pathology Antibodies, Monoclonal / therapeutic use* Arthritis, Rheumatoid / complications*, drug therapy* Female Humans Middle Aged Nephrotic Syndrome / drug therapy, etiology, pathology Serum Amyloid A Protein Tumor Necrosis Factor-alpha / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Serum Amyloid A Protein; 0/Tumor Necrosis Factor-alpha; 0/infliximab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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