Document Detail

The case of a 48 year-old woman with bizarre and complex delusions.
MedLine Citation:
PMID:  20212429     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A 48 year-old woman presented with an 18 month history of bizarre and complex delusions on a background of social, behavioral and cognitive decline over several years. Her psychosis progressed despite receiving high doses of antipsychotics. The patient's father also had a psychotic episode in his 40s. He subsequently developed motor neuron disease, which caused his death at 68 years of age.
INVESTIGATIONS: Physical examination, neuropsychological testing, nerve conduction studies, brain MRI and transcranial magnetic stimulation.
DIAGNOSIS: On the basis of the patient's age at onset of the delusions, imaging findings and family history, a diagnosis of frontotemporal dementia (FTD) was favored over a primary psychotic disorder. The ubiquitin-positive and TAR DNA binding protein 43-positive inclusions that were found at autopsy confirmed the diagnosis of FTD.
MANAGEMENT: The patient was treated with various antipsychotics at high doses; however, her delusions continued to progress. No disease-specific treatments for FTD currently exist.
Clement T Loy; Jillian J Kril; Julian N Trollor; Matthew C Kiernan; John B J Kwok; Steve Vucic; Glenda M Halliday; John R Hodges
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nature reviews. Neurology     Volume:  6     ISSN:  1759-4766     ISO Abbreviation:  Nat Rev Neurol     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-09     Completed Date:  2010-06-04     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  101500072     Medline TA:  Nat Rev Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  175-9     Citation Subset:  IM    
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MeSH Terms
Brain / metabolism,  pathology
Cognition Disorders / etiology
DNA-Binding Proteins / genetics,  metabolism
Delusions / etiology*,  pathology,  psychology
Frontotemporal Dementia / complications*,  diagnosis,  genetics
Magnetic Resonance Imaging / methods
Middle Aged
Neural Conduction / physiology
Neuropsychological Tests
Physical Examination / methods
Grant Support
G9724461//Medical Research Council
Reg. No./Substance:
0/DNA-Binding Proteins; 0/protein TDP-43

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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