| The carotid body and natriuresis: effect of almitrine bismesylate. | |
| | |
MedLine Citation:
|
PMID: 3453062 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Almitrine bismesylate is a peripheral chemoreceptor agonist. When given intravenously to anaesthetized rats it results in a reversible diuresis and natriuresis. The effect is abolished by denervation of the carotid bodies and is still present following vagotomy, when the animal is paralysed and artificially ventilated or following bilateral adrenalectomy. Denervation of the carotid bodies results in a lower resting sodium excretion. In chronically hypoxic rats which have enlarged carotid bodies the natriuretic response to almitrine is grossly diminished. |
| | |
Authors:
|
P A Bardsley; A J Suggett |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Biomedica biochimica acta Volume: 46 ISSN: 0232-766X ISO Abbreviation: Biomed. Biochim. Acta Publication Date: 1987 |
Date Detail:
|
Created Date: 1988-08-09 Completed Date: 1988-08-09 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 8304435 Medline TA: Biomed Biochim Acta Country: GERMANY, EAST |
Other Details:
|
Languages: eng Pagination: 1017-22 Citation Subset: IM |
Affiliation:
|
University Department of Medicine, Royal Hallamshire Hospital, Sheffield, U.K. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenal Glands
/
physiology Almitrine Animals Anoxia / physiopathology Carotid Body / drug effects*, physiology Chemoreceptor Cells / drug effects, physiology Denervation Male Natriuresis / drug effects* Piperazines / pharmacology* Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
|
0/Piperazines; 27469-53-0/Almitrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of almitrine on renal sodium excretion in chemoreceptor denervated spontaneously hypertensive...
Next Document: Influence of infusion of deoxycorticosterone acetate on the responses of kidney function elicited by...