| A carotid body and glomus jugulare paraganglioma secreting norepinephrine. | |
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MedLine Citation:
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PMID: 15251599 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Extra-adrenal paragangliomas (PGOMAs) are rare and can occur anywhere along the sympathetic chain including the carotid body, glomus jugulare, vagal bodies, ganglium tympanicum, larynx, ciliary bodies, organs of Zuckerkandl, urinary bladder, and other locations. These are microscopically identical. The embryological origin is from neural crest cells. One to three percent are reported to be functioning, predominantly secreting norepinephrine. Diagnosis of a functioning PGOMA can be delayed, even when symptoms of catecholamine hypersecretion are present. Furthermore, diagnostic testing and surgery have a significant morbidity if the diagnosis is not considered in advance, as illustrated by the following cases. PGOMAs can be sporadic or familial with an autosomal dominant pattern with variable penetrance. They can be multicentric and associated with other endocrine gland tumors. Benign and malignant PGOMAs have been described, with malignancy being defined by lymph node metastasis. Few cases of functioning glomus jugulare and carotid body tumors have been reported in the medical literature. |
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Authors:
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J L Snitzer; L R Sheeler; E L Bravo; H L Thacker; P Lavertu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists Volume: 1 ISSN: 1530-891X ISO Abbreviation: Endocr Pract Publication Date: 1995 Mar-Apr |
Date Detail:
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Created Date: 2004-07-14 Completed Date: 2005-02-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9607439 Medline TA: Endocr Pract Country: United States |
Other Details:
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Languages: eng Pagination: 82-5 Citation Subset: - |
Affiliation:
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Cleveland Clinic Foundation. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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