Document Detail

Is carnitine essential in children?
MedLine Citation:
PMID:  1864456     Owner:  NLM     Status:  MEDLINE    
Carnitine has a fundamental biological role as a long-chain fatty acid carrier across the mitochondrial membrane and in ketone body formation. Although the body normally synthesizes carnitine, in certain circumstances such as total parenteral nutrition and haemodialysis a dietary supplement may be needed to maintain adequate levels. Several considerations suggest that carnitine is a truly essential nutrient in infancy and in other situations where the energy requirement is particularly high, e.g. pregnancy and breast feeding. There are, for example, congenital deficit syndromes due to enzymatic inadequacies. There is also the possible role of carnitine in serious metabolic disorders such as organic acidaemias and, above all, it has multiple physiological functions in major metabolic pathways which are essential for development and growth.
M Giovannini; C Agostoni; P C Salari
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  The Journal of international medical research     Volume:  19     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:    1991 Mar-Apr
Date Detail:
Created Date:  1991-09-11     Completed Date:  1991-09-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  88-102     Citation Subset:  IM    
Fifth Department of Paediatrics, University of Milan, Italy.
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MeSH Terms
Carnitine / deficiency,  metabolism*,  therapeutic use
Infant, Newborn
Kidney / metabolism
Liver / metabolism
Metabolism, Inborn Errors / physiopathology
Milk, Human / chemistry
Nutritional Requirements
Reg. No./Substance:

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