Document Detail


The cardiovascular unit as a dynamic player in disease and regeneration.
MedLine Citation:
PMID:  19913457     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Cell-mediated cardiac regeneration remains a challenge as a therapeutic option in heart failure, but modest success using experimental models suggests that a better understanding of normal histogenesis will be needed to make progress towards cardiac regeneration. Recent studies of the heart show that the interstitium informs organogenesis and responsiveness to pathological stimuli through continuous bidirectional cross-talk between cardiomyocytes and non-cardiac cells. Here, we introduce the concept of the "cardiovascular unit" (CVU) as a building block of the heart, which includes cardiomyocytes and adjacent capillaries and fibroblasts. We discuss how the CVU might be used as a tool for re-interpreting degenerative changes of the myocardium during aging and hypertrophy, and might represent the hallmark for successful cell therapy strategies in cardiac regeneration.
Authors:
Simonetta Ausoni; Saverio Sartore
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-11
Journal Detail:
Title:  Trends in molecular medicine     Volume:  15     ISSN:  1471-499X     ISO Abbreviation:  Trends Mol Med     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100966035     Medline TA:  Trends Mol Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  543-52     Citation Subset:  IM    
Affiliation:
Department of Biomedical Sciences, University of Padova, Viale G. Colombo, 3- 35121 Padova, Italy. simonetta.ausoni@unipd.it
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