Document Detail

The cardiovascular system in cystic fibrosis.
MedLine Citation:
PMID:  6752859     Owner:  NLM     Status:  MEDLINE    
Available evidence indicates that cystic fibrosis causes widespread involvement of the cardiovascular system. Aside from the heart, unusual aberrations have been observed in the bronchial arteries, the aorta, and the systemic capillaries. Of all cardiovascular complications, cor pulmonale is the most serious. Recognition of a significant degree of cor pulmonale is generally possible on the basis of the severity of the underlying disease. Although echocardiography and radionuclide angiography are valuable research tools in the study of cor pulmonale in cystic fibrosis, they add little, from a practical standpoint, to the management of the patient. The basis of cor pulmonale is hypoxemia and unless this is relieved, no enduring effect can be expected from therapy directed toward the heart. Inasmuch as cystic fibrosis is a progressive disease, cor pulmonale is also progressive. At best, cardiac treatment represents a delaying action that may provide more time to combat an intercurrent infection.
A J Moss
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pediatrics     Volume:  70     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1982 Nov 
Date Detail:
Created Date:  1982-12-18     Completed Date:  1982-12-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  728-41     Citation Subset:  AIM; IM    
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MeSH Terms
Aortic Diseases / etiology
Bronchial Arteries
Cardiomyopathies / etiology
Cardiovascular Diseases / etiology*
Cystic Fibrosis / complications*,  physiopathology
Heart / radionuclide imaging
Pulmonary Heart Disease / etiology*,  physiopathology,  therapy

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