Document Detail


The cardiovascular and subjective effects of intravenous cocaine and morphine combinations in humans.
MedLine Citation:
PMID:  1578376     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intravenous cocaine (COC) and morphine (MOR) combinations ("speedballs") were administered to nine research volunteers during 12 daily experimental sessions. During each session, a single dose of MOR sulfate (0, 5 and 10 mg/70 kg) was administered i.v. in combination with a single dose of COC hydrochloride (0, 8, 16 and 32 mg/70 kg). All possible COC-MOR combinations were each tested once. Measures of subjective effects were obtained repeatedly, heart rate, diastolic and systolic blood pressure were sampled every 2 min and blood levels of COC and MOR were obtained at three time points. Both COC and MOR alone significantly increased peak heart rate, diastolic pressure and systolic pressure. The cardiovascular effects of COC were larger and longer in duration than morphine, as indicated by larger area under the curve measures compared to MOR. COC alone increased visual analog scales ratings of "stimulated" and A scores of the Addiction Research Center Inventory, whereas MOR alone increased opiate symptoms and ratings of "sedated" and both drugs increased ratings of "high." For the most part, the cardiovascular effects of COC-MOR combinations could be predicted by the effects of COC alone, and the subjective effects of the combinations could be predicted by either drug alone. The drug combination produced increases in cardiovascular and subjective effects that were less than predicted by an effect addition model of drug interaction. The disposition of both COC and MOR was unaffected by the presence of the other drug. These results suggest that the self-administration of this drug combination may be related to a unique profile of opiate and stimulant effects instead of an alteration in the effects produced by either drug alone.
Authors:
R W Foltin; M W Fischman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pharmacology and experimental therapeutics     Volume:  261     ISSN:  0022-3565     ISO Abbreviation:  J. Pharmacol. Exp. Ther.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-06-05     Completed Date:  1992-06-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376362     Medline TA:  J Pharmacol Exp Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  623-32     Citation Subset:  IM    
Affiliation:
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure / drug effects*
Cocaine / blood,  pharmacokinetics,  pharmacology*
Drug Combinations
Heart Rate / drug effects*
Humans
Injections, Intravenous
Male
Morphine / blood,  pharmacokinetics,  pharmacology*
Psychomotor Performance / drug effects*
Questionnaires
Grant Support
ID/Acronym/Agency:
DA-03818/DA/NIDA NIH HHS; MOI-RR-00035/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Drug Combinations; 50-36-2/Cocaine; 57-27-2/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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