Document Detail

The cardiovascular risk factor, soluble CD40 ligand (CD154), but not soluble CD40 is lowered by ultra-endurance exercise in athletes.
MedLine Citation:
PMID:  18728056     Owner:  NLM     Status:  In-Process    
BACKGROUND: Soluble CD40 ligand (sCD40L) is a powerful marker of cardiovascular risk. Exercise is known to decrease cardiovascular risk, but the impact of ultra-endurance exercise on sCD40L responses is unknown.
OBJECTIVE: To examine the relationship between ultra-endurance exercise in trained athletes and levels of sCD40L and its natural ligand sCD40.
DESIGN: Control-trial, crossover design, exercise intervention study of sCD40L and sCD40 levels.
SETTING: Outdoor exercise and laboratory testing, single centre study, School of Physical Education, University of Otago, New Zealand.
PARTICIPANTS: Nine trained ultra-endurance athletes.
INTERVENTIONS: Athletes exercised (cycled and jogged) for 17 of 24 h. Venous blood was sampled at baseline and serially throughout exercise and 24 and 48 h after exercise. The athletes completed a 24 h control trial on a separate occasion, in randomised order.
MAIN OUTCOME MEASUREMENTS: Mean levels of sCD40L and sCD40 during exercise and rest with 95% CIs.
RESULTS: sCD40L levels dropped steadily from baseline (median 4128 pg/ml) to a measured nadir at 24 h following exercise (median 1409 pg/ml) (p=0.01). The levels had started to rise again by 48 h after exercise. When measured as a group, sCD40L levels remained constant during a control rest period. sCD40 levels remained constant on both exercise and control days.
CONCLUSION: Ultra-endurance exercise lowers the levels of the cardiovascular risk marker sCD40L in athletes. These results raise the possibility that exercise-induced changes in sCD40L may provide one of the mechanisms by which exercise lowers cardiovascular risk.
Liesel Geertsema; Samuel J E Lucas; James D Cotter; Barry Hock; Judy McKenzie; Liam J Fernyhough
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Publication Detail:
Type:  Journal Article     Date:  2008-08-26
Journal Detail:
Title:  British journal of sports medicine     Volume:  45     ISSN:  1473-0480     ISO Abbreviation:  Br J Sports Med     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0432520     Medline TA:  Br J Sports Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  42-5     Citation Subset:  IM    
Australasian College of Sports Medicine, Christchurch, New Zealand.
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