| The cardiovascular pharmacology and hemodynamic activity of tazolol, a selective myocardial beta-stimulant. | |
| | |
MedLine Citation:
|
PMID: 10864 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The pharmacology and hemodynamics of tazolol (1-iso-propylamino-3-(2-thiazoloxy)-2-propranolol HC1), a selective myocardial beta-stimulant, were studied in pentobarbital anesthetized dogs. Tazolol, i.v., increased myocardial contractile force and heart rate, but induced only minimal changes in arterial pressure. The cardiac effects of tazolol were blocked by pretreatment with the beta-blockers propranolol or practolol and inhibited in animals made tachyphylactic to amphetamine. They were not altered by pretreatment with hexamehtonium, atropine or reserpine. Tazolol increased left circumflex coronary artery flow to a far greater extent than a dose level of isoproterenol which produced a greater increase in cardiac output. Tazolol also increased superior mesenteric artery flow, whereas isoproterenol decreased it. Renal artery flow was not altered. Tazolol was also found to be orally active and to possess some mild general beta-blocking activity. |
| | |
Authors:
|
A M Strosberg |
Related Documents
:
|
10854624 - Hypercapnia-induced contraction in isolated pulmonary arteries is endothelium-dependent. 12614794 - Surgical radiofrequency ablation induces coronary endothelial dysfunction in porcine co... 8314924 - Endotoxin decreases the contractile responses of the porcine basilar artery to vasoacti... 3394574 - Heterogeneity in the response to histamine of isolated dog arteries. 8664004 - Arterial and venous conduits for coronary artery bypass. a current review. 2240714 - A new geometric procedure for in vivo pulsed doppler evaluation of velocity distributio... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Archives internationales de pharmacodynamie et de thérapie Volume: 222 ISSN: 0003-9780 ISO Abbreviation: Arch Int Pharmacodyn Ther Publication Date: 1976 Aug |
Date Detail:
|
Created Date: 1976-12-30 Completed Date: 1976-12-30 Revised Date: 2012-01-12 |
Medline Journal Info:
|
Nlm Unique ID: 0405353 Medline TA: Arch Int Pharmacodyn Ther Country: BELGIUM |
Other Details:
|
Languages: eng Pagination: 200-15 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenergic beta-Agonists
/
pharmacology* Amphetamine / pharmacology Animals Blood Pressure / drug effects Dogs Drug Interactions Female Heart Rate / drug effects Hemodynamics / drug effects* Isoproterenol / pharmacology Male Myocardial Contraction / drug effects Propanolamines / pharmacology* Propranolol / pharmacology Reserpine / pharmacology Thiazoles / pharmacology Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic beta-Agonists; 0/Propanolamines; 0/Thiazoles; 300-62-9/Amphetamine; 50-55-5/Reserpine; 525-66-6/Propranolol; 7683-59-2/Isoproterenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Selective blocking properties of chloro acetyl catechol (CAC) on the alpha-adrenergic receptor.
Next Document: Influence of adrenaline, dibenamine and dopamine on acidosis, hemoconcentration and lethality in pro...