Document Detail

The cardiovascular effects of trimazosin.
MedLine Citation:
PMID:  6120084     Owner:  NLM     Status:  MEDLINE    
Trimazosin, a quinazoline related to the antihypertensive agent prazosin, was studied in anesthetized animals and isolated tissue preparations for effects related to cardiovascular activity. In cats, there was no evidence for ganglion-, adrenergic neurons-, or beta -adrenoceptor blockade, but the pressor effect of epinephrine was reversed. In dogs, the hypotensive effect to trimazosin was due to selective blockade of vascular alpha 1-adrenoceptors. Trimazosin competitively antagonized norepinephrine-induced contraction of rabbit aorta, and in rabbit pulmonary artery it selectively blocked postsynaptic alpha 1-adrenoceptors. In spinal-pithed dogs and rats trimazosin lowered blood pressure, in contrast to the lack of such activity reported for prazosin in pithed rats. It is concluded that trimazosin lowers blood pressure by selective blockade of alpha 1-adrenoceptors, and has, in addition, a hypotensive effect in pithed animals which is not due to alpha -adrenoceptor blockade.
J W Constantine; H J Hess
Related Documents :
7828384 - Celiprolol and propranolol for unstable angina pectoris.
11818034 - Adaptations to iron deficiency: cardiac functional responsiveness to norepinephrine, ar...
24317204 - Real-time detection of gastric insufflation related to facemask pressure-controlled ven...
11863244 - Effect of amlodipine compared to atenolol on small arteries of previously untreated ess...
20729724 - Accuracy of the visomat handy wrist blood pressure measuring device according to the in...
25451774 - Influence of different substrates on the performance of a two-stage high pressure anaer...
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  74     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1981 Sep 
Date Detail:
Created Date:  1982-04-20     Completed Date:  1982-04-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  227-38     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adrenergic alpha-Antagonists / pharmacology*
Antihypertensive Agents / pharmacology*
Blood Pressure / drug effects*
Dose-Response Relationship, Drug
Epinephrine / pharmacology
Nictitating Membrane / drug effects
Norepinephrine / pharmacology
Phenoxybenzamine / pharmacology
Phenylephrine / pharmacology
Piperazines / pharmacology*
Propranolol / pharmacology
Quinazolines / pharmacology*
Vasoconstriction / drug effects
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Antihypertensive Agents; 0/Piperazines; 0/Quinazolines; 35795-16-5/trimazosin; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 525-66-6/Propranolol; 59-42-7/Phenylephrine; 59-96-1/Phenoxybenzamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Brain histamine H1- and H2-receptors and histamine-sensitive adenylate cyclase: effects of antipsych...
Next Document:  The action of six antagonists of the excitatory amino acids on neurones of the rat spinal cord.