Document Detail


The cardiovascular effects of trimazosin.
MedLine Citation:
PMID:  6120084     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Trimazosin, a quinazoline related to the antihypertensive agent prazosin, was studied in anesthetized animals and isolated tissue preparations for effects related to cardiovascular activity. In cats, there was no evidence for ganglion-, adrenergic neurons-, or beta -adrenoceptor blockade, but the pressor effect of epinephrine was reversed. In dogs, the hypotensive effect to trimazosin was due to selective blockade of vascular alpha 1-adrenoceptors. Trimazosin competitively antagonized norepinephrine-induced contraction of rabbit aorta, and in rabbit pulmonary artery it selectively blocked postsynaptic alpha 1-adrenoceptors. In spinal-pithed dogs and rats trimazosin lowered blood pressure, in contrast to the lack of such activity reported for prazosin in pithed rats. It is concluded that trimazosin lowers blood pressure by selective blockade of alpha 1-adrenoceptors, and has, in addition, a hypotensive effect in pithed animals which is not due to alpha -adrenoceptor blockade.
Authors:
J W Constantine; H J Hess
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  74     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1981 Sep 
Date Detail:
Created Date:  1982-04-20     Completed Date:  1982-04-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  227-38     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Antagonists / pharmacology*
Animals
Antihypertensive Agents / pharmacology*
Blood Pressure / drug effects*
Cats
Dogs
Dose-Response Relationship, Drug
Epinephrine / pharmacology
Female
Hindlimb
Male
Nictitating Membrane / drug effects
Norepinephrine / pharmacology
Phenoxybenzamine / pharmacology
Phenylephrine / pharmacology
Piperazines / pharmacology*
Propranolol / pharmacology
Quinazolines / pharmacology*
Rabbits
Rats
Vasoconstriction / drug effects
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Antihypertensive Agents; 0/Piperazines; 0/Quinazolines; 35795-16-5/trimazosin; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 525-66-6/Propranolol; 59-42-7/Phenylephrine; 59-96-1/Phenoxybenzamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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