Document Detail

The cardiovascular effects of the surfactant pluronic F68 in anesthetized dogs.
MedLine Citation:
PMID:  2096635     Owner:  NLM     Status:  MEDLINE    
We tested the cardiovascular actions of the surfactant Pluronic F68 by infusing it into anesthetized dogs, in doses approximating those which would be received when Fluosol-DA were used to resuscitate moderate or severe hemorrhage (0.66 and 1.11 g/Kg). In order to alleviate the reactions to Pluronic, the surfactant was purified by treatment with activated charcoal and the dogs were pretreated with corticosterone. Pluronic F68 caused dose-dependent increments in cardiac filling pressures and in systemic and pulmonary arterial blood pressure. Heart rate and contractility remained unchanged. There was an increase in the cardiac output which was dose-dependent and unrelated to the filling pressures. Regional blood flow, as determined by radionuclide-labelled microspheres, tended to increase, but only that to the heart, kidney cortex and lung (bronchial arterial) increased to a statistically significant extent. It would appear that Pluronic F68, when purified with charcoal and after steroid prophylaxis, possesses significant hemorheologic and cardiovascular effects, indicating the need for further investigation of various purification methods and the effects of purified preparations.
A M Gosselin; G P Biro
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  277     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  1990  
Date Detail:
Created Date:  1991-07-15     Completed Date:  1991-07-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  291-9     Citation Subset:  IM    
Department of Physiology, Faculty of Medicine, University of Ottawa, Canada.
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MeSH Terms
Blood Flow Velocity / drug effects
Blood Pressure / drug effects
Cardiovascular Physiological Phenomena
Cardiovascular System / drug effects*
Hemodynamics / drug effects
Poloxalene / isolation & purification,  pharmacology*
Regional Blood Flow / drug effects
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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