Document Detail

The cardiovascular effects of normobaric hyperoxia in patients with heart rate fixed by permanent pacemaker.
MedLine Citation:
PMID:  20003116     Owner:  NLM     Status:  MEDLINE    
To investigate whether the established reductions in heart rate and cardiac output with hyperoxia in humans are primary effects or secondary to increases in systemic vascular resistance, we paced the hearts of nine patients with permanent pacemakers at a fixed rate when breathing either medical air (inspired O(2) fraction 0.21) or oxygen (inspired O(2) fraction 0.80) in a randomised, double-blind fashion. A thoracic bio-impedance machine was used to measure heart rate, stroke volume and blood pressure and calculate cardiac index and systemic vascular resistance index. Oxygen caused no change in cardiac index (p = 0.18), stroke index (p = 0.44) or blood pressure (p = 0.52) but caused a small (5.5%) increase in systemic vascular resistance index (p = 0.03). This suggests that hyperoxia has no direct myocardial depressant effects, but that the changes in cardiac output reported in previous studies are secondary to changes in systemic vascular resistance.
K J Anderson; J M Harten; M G Booth; C Berry; A McConnachie; A C Rankin; J Kinsella
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2009-12-01
Journal Detail:
Title:  Anaesthesia     Volume:  65     ISSN:  1365-2044     ISO Abbreviation:  Anaesthesia     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-04-20     Completed Date:  2010-05-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  167-71     Citation Subset:  AIM; IM    
Department of Anaesthesia, University of Glasgow, Glasgow, UK.
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MeSH Terms
Cardiac Output / drug effects,  physiology
Double-Blind Method
Heart Rate / drug effects,  physiology
Hemodynamics / drug effects*,  physiology
Middle Aged
Oxygen / pharmacology*
Oxygen Inhalation Therapy*
Pacemaker, Artificial*
Vascular Resistance / drug effects,  physiology
Young Adult
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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