Document Detail


The cardiovascular effects of nebulized adenosine in man.
MedLine Citation:
PMID:  3169116     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have studied the cardiovascular effects of inhaled adenosine in healthy subjects. Adenosine at a concentration of 5 mg.ml-1 is absorbed and produces an increase in heart rate of 6-7 beats per min, blood pressure and skin temperature being unaltered. The rise in heart rate is less than that seen with an infusion of a comparable dose and is unlikely to be adequate for therapeutic termination of supraventricular tachycardia. Higher doses are limited by the poor solubility of adenosine. Inhalation as a method of delivering adenosine has possibilities as an alternative route of administration, but some practical problems remain to be overcome.
Authors:
M O Coupe; B Clarke; A Robson; P J Oldershaw; P J Barnes
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  34     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1988  
Date Detail:
Created Date:  1988-10-31     Completed Date:  1988-10-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  645-7     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Brompton Hospital, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Adenosine / administration & dosage,  pharmacology*
Administration, Inhalation
Blood Pressure / drug effects*
Heart Rate / drug effects*
Humans
Nebulizers and Vaporizers
Skin Temperature / drug effects*
Chemical
Reg. No./Substance:
58-61-7/Adenosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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