| The cardiovascular effects of nebulized adenosine in man. | |
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MedLine Citation:
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PMID: 3169116 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have studied the cardiovascular effects of inhaled adenosine in healthy subjects. Adenosine at a concentration of 5 mg.ml-1 is absorbed and produces an increase in heart rate of 6-7 beats per min, blood pressure and skin temperature being unaltered. The rise in heart rate is less than that seen with an infusion of a comparable dose and is unlikely to be adequate for therapeutic termination of supraventricular tachycardia. Higher doses are limited by the poor solubility of adenosine. Inhalation as a method of delivering adenosine has possibilities as an alternative route of administration, but some practical problems remain to be overcome. |
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Authors:
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M O Coupe; B Clarke; A Robson; P J Oldershaw; P J Barnes |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of clinical pharmacology Volume: 34 ISSN: 0031-6970 ISO Abbreviation: Eur. J. Clin. Pharmacol. Publication Date: 1988 |
Date Detail:
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Created Date: 1988-10-31 Completed Date: 1988-10-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1256165 Medline TA: Eur J Clin Pharmacol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 645-7 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Brompton Hospital, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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administration & dosage,
pharmacology* Administration, Inhalation Blood Pressure / drug effects* Heart Rate / drug effects* Humans Nebulizers and Vaporizers Skin Temperature / drug effects* |
| Chemical | |
Reg. No./Substance:
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58-61-7/Adenosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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